The lateral aspect of the superior frontal gyrus is a large and functionally heterogeneous brain region, ie the dorsal lateral prefrontal cortex (DLPFC)76. The DLPFC provides top-down control of sensory and affective processes. The connectivity between VSi and DLPFC has been shown to play a role in pain regulation. The previous study has identified a novel corticostriatal circuit in the regulation of chronic neuropathic pain which consistent with our findings. In sum, these regions, predominantly right lateralized, have been implicated in high-level pain-modulatory mechanisms that are recruited when the pain experience is altered by changing expectations, beliefs, and judgments about pain77–82.
Our results highlight the role of the lateral
Our results highlight the role of the lateral