Cell Mediated Immunity And Work For An Effective Defence System Against Infectious Microorganisms And Other Foreign Substances

1096 Words Jan 18th, 2016 5 Pages
Leukocytes are one of the groups that comprise of the blood, which are critical for providing a defence system against “infectious microorganisms and other foreign substances”. Lymphocytes are a subgroup of white blood cells that originate from stem cells in the bone marrow and determine which specific type of immune response is used against these pathogens. The lymphocytes that migrate to the thymus later mature into target cells which differentiate into helper, supressor or cytotoxic T cells, which are embedded into peripheral tissues or circulate the body via the bloodstream or lymphatic system. T cells are involved in cell mediated immunity and work by recognising antigens with major histocompatibility complex (MHC) molecules on the surface. This recognition is mediated by the T cell receptors, a complex protein that varies amongst t cells to aid their function, this will be explored through this essay. The body then rapidly begins to produce T cells, each with numerous specific T cell receptors (TCR) on its surface allowing for faster detection of an intruder and increased chance of binding when encountered.This essay will explore the variations amongst the structure of the different T Cells and how this relates to its function.

TCR was discovered to be is cell surface heterodimer that is composed typically of of a beta chain and an acidic alpha chain, however approximately 5% of T cells are made up of delta and gamma chains. Each chain is composed of a variable…

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