Causes And Treatment Of Polycystic Kidney Disease Essay

1633 Words Dec 13th, 2016 7 Pages
The kidney is an organ in our body that removes waste and balance fluids. Polycystic kidney disease is a disorder that causes many fluid-filled sacs to build up. Those sacs are called cysts, that ends up on the kidneys. When the fluid - filled cysts cover the whole kidney, it cause the kidney to become enlarged.The cysts can lead to kidney failure and development in other organs in the body, in most cases the liver as well.
Mode of Inheritance and Biological Mechanisms
Polycystic kidney disease is a disorder where scientist and doctors still do not understand. The gene of where the mutation occurs is found but the complete mechanisms that allows the disorder to manifested is still unknown.But there are two types of mode of inheritance of polycystic kidney disease. The first type of mode of inheritance of polycystic kidney disease is autosomal dominant polycystic kidney disease (also called ADPKD). Autosomal dominant polycystic kidney disease is caused by mutations in the PKD1 and PKD2 gene. PKD1 is genetically heterogeneous. The PKD1 gene makes a protein called polycystin-1. Polycystin-1 is a protein in the kidney that is most effective before childbirth than in average adult kidneys. Polycystin-1 is a “transmembrane receptor-like protein of unknown function” (genetics book page 464). When polycystin-1 protein enter a kidney cell, one half would be inside the cell and the other would in the outer surface. When the protein is in that position it allows it to interact and…

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