Genetics Involving Pheochromocytomas
Jillian Benson
Baker University School of Nursing
Genetics Involving Pheochromocytomas
Pathophysiology
Pheochromocytomas and paragangliomas are rare, benign tumors that develop from chromaffin cells, which are located in the neuroectodermal tissues around the spinal column and the adrenal glands (Grouzman et al., 2015 and Santos, 2014). Pheochromocytomas are located inside of the adrenal gland, while paragangliomas are located outside of the adrenal gland. These tumors are known to secrete neurotransmitters such as epinephrine and norepinephrine, as well as catecholamines (VanMeter & Hubert, 2014, p. 423). According to a research article written by Eric Grouzmann (2015), “In chromaffin cells and pheochromocytes, norepinephrine (NE) and epinephrine (E) are stored in vesicles where they sustain a passive leakage into the cytoplasm before being recaptured in the vesicle pool” (p.2). This is important because, the enzyme responsible for transforming norepinephrine into epinephrine is only in the adrenal medulla and is …show more content…
Abid, K. (2015). Catecholamine Metabolism in Paraganglioma and Pheochromocytoma: Similar Tumors in Different Sites?. Plos ONE, 10(5), 1-18.
JAMA and Archives Journals. (2010). Study identifies genetic mutations associated with tumor of adrenal gland. ScienceDaily. Retrieved October 12, 2015 from www.sciencedaily.com/releases/2010/12/101214181239.htm
Karasek, D., Shah, U., Frysak, Z., Stratakis, C., & Pacak, K. (2013). An update on the genetics of pheochromocytoma. Journal Of Human Hypertension, 27(3), 141-147.
Santos, P., Pimenta, T., & Taveira-Gomes, A. (2014). Hereditary Pheochromocytoma. International Journal Of Surgical Pathology, 22(5), 393-400.
VanMeter, K. C., and Hubert, R. J. (2014). Gould’s pathophysiology for the health professions (5th ed.). St. Louis, MO: Elsevier
Jillian Benson
Baker University School of Nursing
Genetics Involving Pheochromocytomas
Pathophysiology
Pheochromocytomas and paragangliomas are rare, benign tumors that develop from chromaffin cells, which are located in the neuroectodermal tissues around the spinal column and the adrenal glands (Grouzman et al., 2015 and Santos, 2014). Pheochromocytomas are located inside of the adrenal gland, while paragangliomas are located outside of the adrenal gland. These tumors are known to secrete neurotransmitters such as epinephrine and norepinephrine, as well as catecholamines (VanMeter & Hubert, 2014, p. 423). According to a research article written by Eric Grouzmann (2015), “In chromaffin cells and pheochromocytes, norepinephrine (NE) and epinephrine (E) are stored in vesicles where they sustain a passive leakage into the cytoplasm before being recaptured in the vesicle pool” (p.2). This is important because, the enzyme responsible for transforming norepinephrine into epinephrine is only in the adrenal medulla and is …show more content…
Abid, K. (2015). Catecholamine Metabolism in Paraganglioma and Pheochromocytoma: Similar Tumors in Different Sites?. Plos ONE, 10(5), 1-18.
JAMA and Archives Journals. (2010). Study identifies genetic mutations associated with tumor of adrenal gland. ScienceDaily. Retrieved October 12, 2015 from www.sciencedaily.com/releases/2010/12/101214181239.htm
Karasek, D., Shah, U., Frysak, Z., Stratakis, C., & Pacak, K. (2013). An update on the genetics of pheochromocytoma. Journal Of Human Hypertension, 27(3), 141-147.
Santos, P., Pimenta, T., & Taveira-Gomes, A. (2014). Hereditary Pheochromocytoma. International Journal Of Surgical Pathology, 22(5), 393-400.
VanMeter, K. C., and Hubert, R. J. (2014). Gould’s pathophysiology for the health professions (5th ed.). St. Louis, MO: Elsevier