Case Study Of Lupus Erythematosus

969 Words 4 Pages
Case Study 1
Vivek Poudel
University of Texas at Arlington

In partial fulfillment of the requirements of
N5315 Advanced Pathophysiology
Mary Schira Ph.D., RN, ACNP-BC
September 19, 2017

What causes systemic lupus erythematosus (lupus)? Why did the NP suspect that Sharon may have lupus? (15 pts)

Exact cause of systemic lupus erythematosus (lupus) is not known. It is believed that some people are born with tendency to develop lupus that is triggered by a viral infection, chemical exposure or other unknown environmental factors. Some of the risk factors are female of reproductive age, estrogen-containing contraceptives, inherited genetic predisposition. Certain race like African American, Hispanic and Asian have a higher chance
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The body produces antibodies that attack body’s own tissue and causes damage to the various organs. The process starts with cell apoptosis. During apoptosis cell’s intracellular components like DNA and RNA leaks to extracellular space. T cell activates B cell to release antibodies. Combination of the antigen and antibody forms into an immune complex. The immune complex deposits in tissues of various organs such as kidney, skin, lings, brain, heart etc. The immune complex induces secretion of cytokines which causes inflammation and tissue damage. As immune system attacks different organs, symptoms related to that organ start to appear. The etiology of lupus is not known but it is believed multiple genetic, epigenetic and environmental factors play role to trigger …show more content…
The sensitivity of anti-DNA antibodies for the diagnosis of SLE is relatively low, but it is the most specific test to diagnose the disease. According to Lupus Foundation of America Anti-dsDNA antibodies are seen in approximately 70 percent patients with lupus.
Elevated antiphospholipid antibodies: The antibodies that attack phospholipids, fat in living cells are called antiphospholipid antibodies. These antibodies associated with narrowing of blood vessels, leading to blood clots in veins or arteries in different organs. According to Lupus Foundation of America, nearly 30 percent of people with lupus will test positive for antiphospholipid antibodies. Phospholipids found in lupus are also found in syphilis, the blood test alone cannot distinguish two different diseases. So this test is not very specific to

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