Antimicrobial Agents Act ( Antimicrobial ) Essay

1998 Words Nov 15th, 2016 8 Pages
In order to truly understand the mechanisms of resistance, it is important to understand how antimicrobial agents act. Antimicrobial agents act primarily on vital microbial functions with minimal effects or without affecting host functions [.Byarugaba, D]. However, different antimicrobial agents act in different ways. The understanding of these mechanisms as well as the chemical nature of the antimicrobial agents is the key in understanding of the ways how resistance against their development. Generally, antimicrobial agents may be described as either bacteriostatic or bactericidal [Byarugaba, D]. Bacteriostatic antimicrobial agents only inhibit the growth or reproduction of the bacteria giving the immune system of the host time to clear them from the system. Complete rejection of the bacteria in this case therefore it dependents on the competence of the immune system. Bactericidal agents kill the bacteria and therefore with or without a competent immune system of the host, the bacteria will be dead. However, the mechanism of action of antimicrobial agents can be characterized further based on the structure of the bacteria or the function that is affected by the agents [Byarugaba, D]. These generally include the following:
I. Inhibition of the cell wall synthesis
The Inhibition of the cell wall synthesis is a major class in antibiotic inhibits. Once cell wall synthesis (involving penicillin binding proteins) is inhibited, enzymatic autolysis of the cell wall can occur.…

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