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16 Cards in this Set
- Front
- Back
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List 5 ways to mediate immunopathology
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1. antibody
2. cell 3. cytokine 4. complement 5. nitrous oxide |
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Which type of CD4 cells drive T cell mediated (CD8) response? What cytokines are used?
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TH1 CD4 cells mediate CD8 response. The TH1's secrete TNF-a IL-2 INF-g
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Which type of CD4 cells drive B cell mediated response? What cytokines are secreted?
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TH2 cells drive B cell mediated response. TH2 cells secrete IL-4, 5, 6, 10,
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What are T DTH cells?
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Delayed type hypersensitivity. effector cells that secrete cytokines that inhibiton infection and attract other effector cells
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What are CD25+ fox p3+ T reg cells?
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T cells that participate in antigen specific supprression of immune response, failure to act enhances immune pathology
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List 5 ways that antibodies can block viruses
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1. Block attachment
2. Block endocytosis 3. Block uncoating 4. neutralization after replication starts 5. Aggregation- opsonization and phagocytosis |
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How does complement antiviral
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MAC kills infected (and non infected cells by drift)
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describe how antibodies can contribute to immunopathology
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-non neutralizing Abs create immune complexes
-example Dengue fever=> hemorrhagic fever, if reinfected with a different strain, Abs bind but dont' kill leads to lots of Fc which triggers Macs to release tons of TNFa leading to hypovolemic shock and death |
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What mediates a type I hypersensitivity
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IgE and mast cells
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What mediates a type II hypersensitivity
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antibody and complement
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What mediates a type III hypersensitivity
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Immune complexes, involves complement or NK cells as effectors
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What mediates a type IV hypersensitivity
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CD4+ t cells
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What are two ways that viruses can elicit a type 1 hypersensitivity
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1. Skew immune response, RSV has G protein that pushes TH2 response and generation of IgE
2. Change secretion- virus infected cells release eotaxin which is a chemoattractant for mast cells |
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Which two viruses can lead to a type II hypersensitivity
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1. AIDS-vasculitis
2. HBV hepatitis- glomerular nephritis |
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Name a virus that can cause a type IV hypersensitivity
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HSV -keratitis leading to blindness
Measles-rash |
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Which immune cells are a major factor in HSV induced blindness
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CD4+ delayed type hypersensitive
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