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16 Cards in this Set

  • Front
  • Back
List 5 ways to mediate immunopathology
1. antibody
2. cell
3. cytokine
4. complement
5. nitrous oxide
Which type of CD4 cells drive T cell mediated (CD8) response? What cytokines are used?
TH1 CD4 cells mediate CD8 response. The TH1's secrete TNF-a IL-2 INF-g
Which type of CD4 cells drive B cell mediated response? What cytokines are secreted?
TH2 cells drive B cell mediated response. TH2 cells secrete IL-4, 5, 6, 10,
What are T DTH cells?
Delayed type hypersensitivity. effector cells that secrete cytokines that inhibiton infection and attract other effector cells
What are CD25+ fox p3+ T reg cells?
T cells that participate in antigen specific supprression of immune response, failure to act enhances immune pathology
List 5 ways that antibodies can block viruses
1. Block attachment
2. Block endocytosis
3. Block uncoating
4. neutralization after replication starts
5. Aggregation- opsonization and phagocytosis
How does complement antiviral
MAC kills infected (and non infected cells by drift)
describe how antibodies can contribute to immunopathology
-non neutralizing Abs create immune complexes
-example Dengue fever=> hemorrhagic fever, if reinfected with a different strain, Abs bind but dont' kill leads to lots of Fc which triggers Macs to release tons of TNFa leading to hypovolemic shock and death
What mediates a type I hypersensitivity
IgE and mast cells
What mediates a type II hypersensitivity
antibody and complement
What mediates a type III hypersensitivity
Immune complexes, involves complement or NK cells as effectors
What mediates a type IV hypersensitivity
CD4+ t cells
What are two ways that viruses can elicit a type 1 hypersensitivity
1. Skew immune response, RSV has G protein that pushes TH2 response and generation of IgE
2. Change secretion- virus infected cells release eotaxin which is a chemoattractant for mast cells
Which two viruses can lead to a type II hypersensitivity
1. AIDS-vasculitis
2. HBV hepatitis- glomerular nephritis
Name a virus that can cause a type IV hypersensitivity
HSV -keratitis leading to blindness
Which immune cells are a major factor in HSV induced blindness
CD4+ delayed type hypersensitive