Sq Pharm Exam 2 - Immunosuppressants

Front 1

This immunosuppressant may cause hyperglycemia, PUD and screw with the HPA axis:

Also decreases rls of these two CKs:

Back 1

Corticosteroids

NF-kB and IL2

Front 2

How do T cell suppressants work in general?

What don't they do?

Back 2

(-) calcineurin

They don't do it through BM suppression

Front 3

How does cyclosporine suppress T cells?

How does Tacrolimus do it?

Back 3

Binds cyclophilin to (-) caclineurin

Binds FK506

Front 4

Phenobarb, phenytoin, and rifampin decrease what drug?

Erythromycin, ketoconazole, grapefruit and verapamil increase what drug?

Back 4

Cyclosporine (T cell suppressor)

Cyclosporine

Front 5

What do you have to monitor in your pt on cyclosporine?

Other SEs (4):

Back 5

Renal function - highly nephrotoxic

HTN, hyperglycemia, CNS sxs, *gingival hyperplasia*

Front 6

What drug rescues rejections?

SEs (3):

Back 6

Tacrolimus

Same as cyclosporine plus: insomnia, skin cancer, CI with ACEIs and ARBs

Front 7

This drug decreases T-cell proliferation by blocking IL2:

It also increases ___ and decreases ___:

Back 7

Sirolimus

Increases TAG and suppresses BM profoundly

Front 8

This prodrug decreases purine synth in lymphocytes, inhibs inosine monphosphate DH and cannot be used with antacids:

Ok in preg?

Back 8

Mycophenolate

Nope. Cat X

Front 9

Your pt is being treated with an immunosuppressant that decreases cell prolif. They develop sepsis and a rash. What drug are they likely taking and what are they also infected with?

Back 9

Mycophenolate and probably have CMV

Front 10

This anticancer drug is also used as an immunosuppressant. May cause hemorrhagic cystitis:

Back 10

cyclophosphamide

Front 11

What is the pro-drug of 6-mecaptopurine?

Back 11

Azathioprine

Front 12

What does thalidomide suppress and therefore increase?

Back 12

TNF-a suppressed, increasing IL4, IL5 from TH2 cells

Front 13

This teratogenic enhances CMI, and is often used in MM, GvH, AML, HIV, leprosy:

Back 13

Thalidomide

Front 14

What drug might cause DVT in hemolytic cancers?

It may also cause periph neuropathy, neutropenia, constipation.

Back 14

Thalidomide

Front 15

This foreign IgG may cause lymphoma at the injection site:

Back 15

Atgam

Front 16

Your administer the first dose of an antibody immunosuppressant drug and within 30 mins your pt has flu like sxs, shock, and pulmonary edema:

How does it work?

Back 16

Muromonab

Binds to CD3 on T3 cells; blocks antigen binding

Front 17

These drugs are first line for rejection tx:

What do they bind to?

SEs:

Back 17

Dacluzumab, basiliximab

IL2 on activated T cells

Minimal. Poss anaphylaxis

Front 18

This antibody immunisuppressnat may be used to tx psoriasis:

Back 18

Efaluzumab

Front 19

GCSF may reverse iatrogenic neutropenia. How is it admin?

Risk for use of Epoetin?

Back 19

SubQ or slow IV

Clots. Keep Hbg <12