Sq Pharm Exam 2 - Anticancer Drugs

Front 1

What do these drugs have in common: Methotrexate, hydroxyurea, 6-mercaptopurine?

Back 1

S-phase drugs

Front 2

What do these drugs have in common: vincristine, vinblastine, paclitaxel?

What drug is a G2 phase drug?

Back 2

M-phase drugs

Bleomycin

Front 3

Anticancer tx is more effective in what types of tumors?

Back 3

Small, fast growing, lots growing

Front 4

List the anticancer drug resistance mechs (7):

Back 4

* Dec uptake/inc efflux
* Dec or inc target enzyme
* Altered affinity for target enzyme
* Dec activation of drug
* Inc DNA repair
* Inc use of salvage paths
* Inc glutathione

Front 5

Describe the function of the P-glycoprotein in cell PMs:

Back 5

Normal cell component that is intended to increase efflux of plant toxins.

Front 6

What do these drugs have in common: mechorethamine, cyclophosphamide, chlorambucil, busulfan, carmustine/lomustine, streptozocin, cisplatin?

Back 6

They are all alkylating agents

Front 7

How does cisplatin differ from the other alkylating agents?

Back 7

DNA crosslinker

Front 8

What do these drugs have in common: Methotrexate, mercaptopurine, 5-FU, hydroxyurea?

Back 8

They are all antimetabolites

Front 9

What do these drugs have in common: daunorubicin, doxorubicin, bleomycin, dactinomycin?

Back 9

They are all antineoplastic abx

Front 10

What do these drugs have in common: vincristine, vinblastine, paclitaxel, etoposide, topotecan?

Back 10

Plant alkaloids

Front 11

What do these drugs have in common: tamoxifen, flutamide, trastuzumab?

Back 11

They are all antineoplastic hormones.

Front 12

Vesicants, GI sxs, hair sxs, fertility issues, BM sxs, and teratogenesis are all common issues for what drugs:

Back 12

Pretty much all antineoplastics

Front 13

Describe the MOPP regimen for Hodgkins Lymphoma:

Back 13

Mechlorethamine, Oncovin (vincristine), Prednisone, Procarbazine

Front 14

How might you tx the hyperuricemia caused by mechlorethamine?

Back 14

Alkalinize urine and add allopurinol.

Front 15

Your pts has had CML for years. What drug are they probably on?

Back 15

Chlorambucil

Front 16

This antineoplastic prodrug is metab by P450, is broad spectrum, and will probably cause hemorrhagic cystitis:

May also cause:

Is NOT:

Back 16

Cyclophosphamide

SIADH

Is NOT a vessicant!

Front 17

Why won't resistant tumor cells be able to prevent activation of cyclophosphamide?

Back 17

Because it's a prodrug that is activated in the liver by P450 enzymes

Front 18

This alkyl sulfonate drug used for CML tx may cause hyperuricemia AND pulmonary toxicity

Back 18

Busulfan

Front 19

What phase is cisplatin effective in?

What tumors is it good for (2)?

Major toxicities (2)?

Back 19

S phase.

Solid and epith

Acoustic nerve dmg!, antigenic-->anaphylaxis

Front 20

What does Cisplatin NOT do?

Back 20

Does not supress BM

Front 21

Your pt is being treated for cancer with an alkylating DNA crosslinking agent and comes to you complaining of deafness. What drug are they on?

Back 21

Cisplatin

Front 22

What are the DOC for brain tumors?

What drug class?

Back 22

Carmustine/Lomustine

Alkylating agents/nitrosureas

Front 23

Your pt is receiving tx for a brain tumor. What are the two risks you have to monitor for?

Back 23

Profound myelosuppression and pulmonary toxicity.

Front 24

Which nitrosurea is not used to tx brain tumors?

What is it used for?

Back 24

Streptozocin. Used for panc B cell tumors and does not cause same issues.

Front 25

Your pt is being treated with a prodrug for cancer and comes to you with signs of hyponatremia. What drug do you have to adjust?

Back 25

Cyclophosphamide

Front 26

This folic acid analog is considered an _____ and it's symptoms are improved by ------.

Back 26

Methotrexate is considered and antimetabolite and it's toxicities are made more bearable by lecovorin.

Front 27

Leucovorin + methotrexate =

Leucovorin + 5-FU =

Allopurinol + 6-mercaptopurine =

Back 27

improved SE sxs; dec drug effect

5-FU potentiation

toxicity - must use lower dose for tx of hyperuricemia

Front 28

This antimetabolite anticancer drug is widely used but is also hepatotoxic and can cause pulmonary infiltrates. It's primary mech of resistance is increase in target enzyme.

Back 28

Methotrexate

Front 29

Where is the antimetabolite 5-FU activated?

What does it bind?

Back 29

In the cell.

Binds thymidylate synthase, which is why leucovorin potentiates it.

Front 30

This pyrimidine analog may be used topically for BCC or in a combo for colorectal ca:

Back 30

5-FU.

Front 31

What is the dose-limiting tox for 6-mercaptopurine?

For Daunorubicin/doxirubicin?

Back 31

Myelosuppression

Cardiotoxicity

Front 32

This prodrug purine analog may cause myelosuppression, cholestatic jaundice, and hyperuricemia:

It is converted 1st by ____ and 2nd by____:

Back 32

6-mercaptopurine

HGPRT then xanthine oxidase

Front 33

These antineoplastics bind DNA via intercalation, are not cycle specific, create free radicals:

Back 33

Abx

Front 34

The main mech of daunorubicin and doxirubicin is:

Which one is used more widely?

Back 34

Generates free radicals

Doxorubicin

Front 35

What interesting SE do daun/dox share?

What other drug in this module has this?

Back 35

Red urine

Metronidazole

Front 36

What will increase the negative effects of daun/dox?

How do you treat this?

Back 36

Inc iron

Dexrazoxane (iron chelator)

Front 37

This testicular cancer drug is specific for G2 & M:

Major tox?

Does not cause:

Back 37

Bleomycin

Pulm tox

No BM suppression

Front 38

This drug is often used to treat Wilm's tumor and rhabdomyosarcosis in kids but causes radiation recall:

Back 38

Dactinomycin

Front 39

Are plant alkaloids cycle specific or non?

Back 39

Cycle specific: M phase

Front 40

Vinblastine mneumonics:

Back 40

VinBlastine blasts BM, and is for Ball cancer

Front 41

Which plant alkaloids bind tubulin and prevent assembly?

Back 41

Vins

Front 42

Which plant alkaloid binds tubulin and stabilizes them to arrest mitosis?

Back 42

Paclitaxel

Front 43

Your advanced cancer pt is being tx with a plant alkaloid. They come in c/o periph neuropathy, myalgias, arthralgias, and heart problems:

Back 43

Paclitaxel

Front 44

How does paclitaxel cause all the nasty side effects (probably)?

Back 44

Disrupts axonal transport when it binds microtubules

Front 45

How does one Eradicate Ball Cancer?

Back 45

Etoposide, Bleomycin, Cisplatin (also, vinoBlastine)

Front 46

____ breaks Topo II in ds fashion and ___ breaks TopoI in ss fashion:

Back 46

Etoposide = topo II, ds break, ball ca

Topotecan = topo I, ss break, ovarian ca

Front 47

This drug is often used to decrease CNS edema after radiation and may also be used in Hodgkin's lymphoma:

Back 47

Prednisone

Front 48

These two drugs are often used to tx prostate ca:

Back 48

DES and flutamide

Front 49

What is the major issue assoc with Trastizumab?

What makes it worse?

Back 49

Cardiomyopathy

Use with daun/doxo

Front 50

What do these drugs have in common: dactinomycin, hydroxyurea?

Back 50

Radiation recall

Front 51

What do these drugs have in common: bleomycin, busulfan?

Back 51

Pulm fibrosis

Front 52

What do these drugs have in common: vincristine, paclitaxel?

Back 52

Neuropathy

Front 53

What do these drugs have in common: 6-mercaptopurine, methotrexate, mechlorethamine, busulfan, 5-FU?

Back 53

Hyperuricemia

Front 54

What do these drugs have in common: 6-mercaptopurine, BCNU/CCNU, methotrexate?

Back 54

Hepatotoxicity