(Sketchy) Acetylcholinesterase Inhibitors

Front 1

How do you show acetylcholinesterase degrades acetylcholine?

Back 1

Dumpster of acetyl-cola bottles

Front 2

Acetylcholinesterase inhibitors increase synaptic concentration of ACh

Back 2

Knocked over dumpster with cola bottles rolling out

Front 3

How do you remember the ending for these drugs?

Back 3

Stigma on dumpster, for -stigmine

Front 4

How is it shown there is increased effects of ACh at neuromuscular junction (increased effect at sicotinic receptors)?

Back 4

Skeletal muscle brick wall with motor end plate

Front 5

What disease is treated with acetylcholiesterase inhibitors, how is it shown in sketchy?

Back 5

The "Gravis gang"

Myesthenia gravis

Front 6

What is a good longterm acetylcholinesterase inhibitor for myethenia gravis, how is it shown?

Back 6

Community PRIDE work cleaning up "gravis" graffiti

Pyridostigmine

Front 7

What is a good symptomatic treatment for myesthenia gravis?

Back 7

Neon sign

Neostigmine

Front 8

What are quarternary amines? Give examples

Back 8

Quarternary - Do not penetrate CNS

1a) Pyrostigmine

1b) Neostigmine

1c) Edrophonium

Shown as quarters only on phone booth

Front 9

Explain the tensilon test and what drug is used

Back 9

Test using edrophonium

Tests to see if patient is being under or over-treated since it has such a short half-life

Positive: Reverses muscle weakness in undertreated myesthenia graves patients

Negative: Exacerbates cholinergic crisis

Shown with a high/low tense phone wire

Front 10

What inhibits nicotinic ACh binding at neuromuscular junction?

Back 10

Curare crayons in outlet

Tubocurarine

Pancuronium

Cisatracurium

Front 11

What inhibits neomuscular blockade?

Back 11

Neon sign (neostigmine) owner kicking out kid with crayons

Front 12

What irriversibly causes blockade, potentiating effects of Choline?

Back 12

Succinylcholine (ACh agonist)

Phase-1 Worker getting shocked, irriversibly damaging endplate, which SUCKS

Front 13

What acetylcholinesterase inhibitor can be used to treat urinary retention?

Back 13

Neon sign owner with hose

Neostigmine

Front 14

What can be used to treat atropine overdose?

Back 14

Phys Ed building

Physostigmine

Phys ed teacher taking artist that drew:

Alice in wonderland holding nightshade graffiti on the wall (Atropine)

Front 15

What is Jimson weed?

Back 15

Gym sign

Naturally occurring form of atropine

Front 16

What

Back 16

Can be reversed by physostigmine

Front 17

What drug can reverse peripheral and central cholinergic blockade?

Back 17

Physostigmine

Brain on drugs poster indicating it can pass into CNS

Front 18

What can be caused by acetylcholinesterase inhibitor toxicity?

Back 18

Diarrhea

Urination

Miosis

Bronchspasm

Bradycardia Guy working out using

Lacrimation dumbells by a weak nicotine

Salivation kid showing flaccid paralysis

Sweating

Front 19

What typically causes acetylcholinesterase inhibitor toxicity?

Back 19

Thiols sprays (Insecticides)

Parathion, malathion, echothiophate

Shown by toxic waste guy with green gas

Front 20

What is used to treat insecticide poisening?

Back 20

Pralidoxime

Closing the lid on toxic spray

Front 21

What reverses central and peripheral muscarinic toxicity because Pralidoxime can't pass into CNS?

Back 21

Atropine

Alice on poisen dumpster

Front 22

What is aging of organophosphae-cholinesterase complex?

Back 22

It is the irreversible binding, making pralidoxime ineffective

Old guy spraying isn't working too well

Front 23

What acetyly cholinesterase is useful for alziemers?

Back 23

Galantamine, Rivastigmine, Donepezil

Alzheimer's gala: Reverse the stigma

Elderly are done with puzzle