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52 Cards in this Set

  • Front
  • Back

Titrimetric Analysis

Is a traditional or classical method of quantitative chemical analysis based on determining the quantity of a reagent of known concentration that is required to react completely with the amount of active constituent is sample being analyzed

Titrant

The solution being delivered from the buret

Titrand

Substance being titrated

Titration

Process in which a standard reagent is added to a solution of analyte until the reaction is judged to be complete

Indicator

Often added to the analyte solution to produce an observable physical change

Beaker

Used for mixing, stirring, and heating chemicals

Erlenmeyer flask

Allows easy mixing and swirling of the flask without too much risk of spilling

Graduated cylinder

To measure volume of liquids

Volumetric flask

Used to measure an exact large volume of liquid

Cork

stopper of volumetric flask

Pipette

Measuring an exact small volume of liquid and placing it into another container

Burette

A glass tube that is open at the top and comes to a narrow pointed opening at the bottom

Stopcock

Right above the bottom opening of a burette is a _________ that can be turned to control the amount of liquid being released

Burette

Used for extremely accurate addition of liquid, especially during titration

Aspirator

A common source of contamination

True

TRUE OR FALSE:


Glass reagent bottles are not for alkalis or bases

Standard solution

Solution of known concentration

Analyte

Substance in a sample being analyzed

Equivalence point

When the amount of added titrant is chemically equivalent to the amount of analyte in the sample

End point

When a physical change occurs that is associated with the condition of equivalence

colorless

Phenolphthalein color on acidic side

pink

Phenolphthalein color on basic side

red

methyl red color on acidic side

yellow

methyl red color on basic side

yellow

bromophenol blue color on acidic side

violet

methyl violet color on basic side

yellow

alizarin yellow color on acidic side

red

alizarin yellow color on basic side

phenolphthalein

The indicator used in the neutralization titration of acetic acid with sodium hydroxide

Direct titration

Titrant is added to analyte until a reaction goes to completion

Residual or back titration

Excess reagent is added to the analyte and the excess is determined

Blank titration

It is to be conducted with the use of same quantities of the same reagents treated in the same manner as the solution or mixture containing the portion of the substance under assay, but with the substance itself omitted

Normality

It is defined as the number of equivalents of solute per liter of solution

Primary standard

Standard used for solids

Sodium carbonate

What is the primary standard used in the standardization of 0.1N sulfuric acid

Content uniformity

Assures that the strength of a therapeutic product remains within specified acceptance limit

Content uniformity test

Used to establish within limits that a product has uniform amounts of AI in batch preparations of pharmaceutical dosage

95% - 105%

USP specification for individual assay of NaHCO3

85% - 115%

USP specification for content uniformity of NaHCO3

Quantitative transfer

Transfer of a substance from one container or vessel to another without losing the content

Methyl red

Assay of sodium carbonate tablets indicator

Faintly pink color

Assay of sodium bicarbonate tablet end point

0.1N H2SO4

Assay of sodium bicarbonate tablet titrant

Methyl red

Standardization of 0.1N H2SO4 indicator

sodium carbonate

Titrand used for the standardization of 0.1N H2SO4

0.1N H2SO4

Titrand used for the standardization of 0.1N NaOH

Milk of Magnesia

Antacid suspension; white viscous liquid

Magnesium hydroxide

Active constituent of Milk of Magnesia

0.1N NaOH

titrant used in the assay of milk of magnesia

methyl red

Indicator used in the assay of milk of magnesia

7-8.5%

assay of milk of magnesia USP limit

Yellow

Assay of milk of magnesia end point