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10 Cards in this Set

  • Front
  • Back
What effect does CCK have on the gallbadder?
causes contraction of the gallbladder and relaxation of the sphincter of Oddi (bile is ejected in spurts)
What stimulates CCK release?
small peptides and fatty acids in duodenum (bile is needed to emulsify and absorb lipids)
What two substances cause contraction of the gallbladder?
ACh and CCK
How are bile acids recirculated to the liver?
Na-bile acid cotransporter in terminal ileum delivers bile to portal blood
Why are bile acids not recirculated until they reach the terminal ileum?
so that they are present for maximal r/a of lipids throughout the upper small intestine
What effect would ileal resection have on stool?
causes steatorrhea
What is the advantage of the liver converting bile acids into bile salts?
bile salts are much more soluble (pK b/t 1-4) in duodenum (pK b/t 3-5); in duod bile salts will be in ionized form
What is the role of the gall bladder epithelial cells?
absorb water and ions in an isosmotic fashion, thus concentrating the organic components
What is the negative feedback regulation of bile acid synthesis?
bile salts feed back and inhibit rate-limiting enzyme in bile acid biosynthetic pathway in liver
What are the regulatory effects when bile salts are recirculated to the liver?
inhibits bile acid synthesis, and stimulates biliary s/c (choleretic effect)