Immunotherapy

Front 1

What are the classws of immunotherapy agents?

Back 1

Immunoactivatiin, immunosupresion, vaccines and antibodies

Front 2

What are immune restoration drugs used for?

Back 2

Used for chemo-induced or drug-induced leukopenias.

Front 3

With which drugs must you monito the WBC count?

Back 3

ticlopidine, clozapine, propylthiouracil and chloramphenicol

Front 4

What is filgrastim? And what is its most common FX?

Back 4

G-CSF; bone pain

Front 5

Which form of G-CSF allow for 1 dose per chemo cycle and which needs 14 dails doses?

Back 5

pegylated-- 1 dose
nonpegy-- 14

Front 6

What is sargrmostim and whats its most common FX?

Back 6

GM-CSF; bone pain and flu-like syndrome

Front 7

Which agent is abused in long distance sports?

Back 7

erythropoietin

Front 8

What drug is used for treating anemias < 28 Hct?

Back 8

erythropoietin

Front 9

What sidw effects does EPO have?

Back 9

blood thickens -- clotting, strokes and MI

Front 10

Which agent are selective and don't inhibit the bone marrow?

Back 10

cyclosporine, sirolimus and tacrilimus

Front 11

What agent inhibits arachidonic acid formation?

Back 11

glucocorticoids

Front 12

How are glucocortioids classified?

Back 12

non-selective and anti-proliferative

Front 13

How does cyclosporin function?

Back 13

IL2 inhibition

cyclosporin + cyclophylin --> bind calcineurn and inhibit NFAT

Front 14

Describe tacrolimus' MOA.

Back 14

Binds FK protein and inhibits calcineurin.
Inhibits IL2

Front 15

Describe sirolimus' MOA.

Back 15

Binds FK and block IL2 receptor.

also inhibits mTOR and locks cell in G1 phase

Front 16

Which of the immune selectice agents have synergy together?

Back 16

sirolimus and cyclosporine

Front 17

Which if the selective agents is the least nephrotoxic?

Back 17

Sirolimus

Front 18

Kidney transplant pt taking cyclosporine, glucocortcoids amd basiliximab to prevent rejection, but inflammation continues 2 months later. What do you do?

Back 18

lower cyclosporine and add sirolimus (not as nephrotoxic).

Front 19

What are cytokine inhibitors?

Back 19

Monoclonal antibodies that directly inhibit cytokines/receptors.

Front 20

What are the contraindications for vaccines?

Back 20

Anaphylactic rxn to previous administration, live vaccines in immunocompromised pts, current disease.

Front 21

What is the TDap vaccine for and when do yoj give it?

Back 21

tetanus, diohteria and pertussis
2, 4, 6, 15 months and 4 years

Front 22

What is the MMR vaccine for and when do you give it?

Back 22

measles, mumps and rubella
12 months, 4 years

Front 23

Whe n do u give the varicella zoster vaccine?

Back 23

12 mo. and 2 for teens

Front 24

HepB

Back 24

at birth, 1 month, 6-9 months

Front 25

What is the PCV vaccine for?

Back 25

strep. pneumo
2, 4, 6, 12 months

Front 26

When do you give the influenza shot?

Back 26

once a year beginning at 6 mo.

Front 27

What shot do you need to give 12 y/o?

Back 27

TDaP, meningococcal, HPV

Front 28

What types of flu vaccines are there?

Back 28

Quadrivalent inactivated and live-attenuated/trivalent (not for low immune pts)

Front 29

Which vaccine has a booster shot every 10 years?

Back 29

tetanus

Front 30

What shot is recommended for pts > 50 yrs?

Back 30

Herpes zoster

Front 31

HPV vaccine is against which strains? Ages?

Back 31

6, 11, 16, 18

as early as 9 yrs ; recommended is 11-26 yrs