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6 Cards in this Set
- Front
- Back
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What is the most common chronic skin condition treated by physicians and is seen in 85% of adolescents and young adults?
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acne
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What is the pathogenesis of acne?
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multifactorial
includes hyperkeratosis with blockage of the pilosebaceous canal, increased growth of Proprionibacterium acnes, overproduction of sebum, and inflammation. Androgen stimulation increases sebaceous glands production causing increased cell turnover and cohesiveness of keratinocytes at the pilosebaceous canal. This causes the keratinous material in the follicle to become more sticky and block the canal The blocked pilosebaceous gland produces a small cystic swelling causing a raised area referred to as a microcomedome |
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What is a whitehead and blackhead?
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whitehead: the mouth of the pilosebaceous canal remains closed
blackhead: the mouth of the pilosebaceous canal opens |
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What bacterium causes acne?
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sebum, dead cells, and obstructed ducts is a great place for the over produciton of Propionibacterium acne
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Where is P acne found?
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Part of nl flora
gram (-) anaerobic diphtheroid bacteria secretes a low molecular weight chemotactic factor and lipase enzyme that breaks down triglycerides of sebum into free fatty acids - this breakdown causes irritiation of the follicular walls which leads to the papules on skin |
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What cells are involve in cyst formation?
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neutrophils release hydrolase which disrupts the integritiy of the follicular wall which damages the underlying dermis this forms a pustule --> If this inflammation continues it will eventually form a nodule and subsequently a cyst
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