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10 Cards in this Set

  • Front
  • Back
unwind the parental double helix.

SIngle-strand binding protein
stabilize the unwound parental DNA.

The leading strand is synthesized continuously in the 5'→3'...
direction by DNA polymerase.
The lagging strand is synthesized discontinuously.

RNA primase synthesizes a short RNA primer which is then extended by...
DNA polymerase.
DNA polymerase digests RNA primer and replaces it with
DNA Ligase joins the...
discontinuous fragments of the lagging strand.
Watson and Crick predicted a semi-conservative model of DNA replication:
When a DNA double helix replicates, each daughter molecule has one old strand (derived or conserved from the parent molecule) and one newly made strand.

Origin of Replication, Ori

Helicases - Enzymes that untwist the double helix
Single-strand binding protein: binds to and stabilizes singles-stranded DNA until it can be used as a template

Topoisomerase: corrects "over winding" ahead of replication forks by breaking, swiveling and rejoining DNA strands
DNA polymerase - The main enzyme of DNA replication.: CAN ONLY ADD NEW NUCLEOTIDES IN THE 5' → 3' DIRECTION!
RNA Primer Synthesis
-An enzyme called primase can start an RNA chain from scratch and adds RNA nucleotides one at a time using the parental DNA as a template.

---Primase builds a new chain ("primer")_ in the 5' → 3' direction.

- The primer is a short (5-10 nucleotides long) RNA sequence.
- The 3' end of the primer serves as the starting point for the new DNA strand.'
The lagging strand of DNA replication is synthesized as a series of segments called Okazaki fragments.
To elongate the strand, DNA polymerase must work away from the replication fork in the opposite direction from the leading strand.