Cutaneous Manifestations Of Systemic Disease

Front 1

What are the ssx of discoid LE?

Back 1

1. Above the neck

2. Scaly, erythematous, atrophic plaques

3. Scarring, atrophy, and pigment changes

Front 2

What are the ssx of subacute cutaneous LE?

Back 2

1. Leukopenia

2. Arthralgia

3. Psoriasis-like polycyclic annular lesions

4. Shawl distribution

Front 3

What antibodies are usually positive in SCLE?

Back 3

1. ANA

2. Anti-Ro/SSA

Front 4

What are the ssx of SLE?

Back 4

1. Malar rash

2. 4/11 other criteria

Front 5

For what type of lupus is ANA most sensitive?

Back 5

1. SLE

Front 6

How do you tx DLE, SCLE, and SLE?

Back 6

1. Sunscreen

2. Hydroxychloroquine

3. Dapsone

4. Steroids

Front 7

What are the ssx of morphea scleroderma?

Back 7

1. Rose or violaceous macules

2. Become smooth, hard, depressed, and yellowish-white

3. Common on trunk

Front 8

What are the ssx of linear scleroderma?

Back 8

1. Lesions that follow lines of Blaschko

2. Parasagittal lesions on frontal scalp extend down onto forehead= En coupe de sabre

Front 9

What are the ssx of CREST syndrome?

Back 9

1. Calcinosis

2. Raynaud

3. Esophageal dysmotility

4. Sclerodactyly

5. Telangiectasias

Anti-centromere antibodies

Front 10

What are the ssx of PSS?

Back 10

1. Raynaud

2. Thickening of dermal collagen

3. Fibrosis and vascular abnormalities of internal organs

4. Sclerodactyly

5. Digital pitting scars of fingertips

Front 11

What is the major cause of death in PSS?

Back 11

1. Pulmonary disease

Front 12

What antibodies are positive in PSS?

Back 12

1. Anti Scl-70---- anti-topoisomerase-1

Front 13

How do you tx morphea?

Back 13

1. Intralesional steroids

Front 14

How do you tx Raynaud's?

Back 14

1. CCB--- nifedipine

2. Avoid cold

3. Don't smoke

Front 15

How do you tx PSS?

Back 15

1. Cyclophosphamide helps

2. Phototx

Front 16

What are the ssx of dermatomyositis?

Back 16

1. Heliotrope rash

2. Gottron's papules

3. Shawl sign--- telangiectasias of upper chest/shoulder

4. Symmetrical proximal muscle weakness

Front 17

What antibodies are associated with dermatomyositis?

Back 17

1. Positive anti-Jo-1

2. Anti-Mi-2 for skin disease

Front 18

How do you tx dermatomyositis?

Back 18

1. Prednisone

2. Immunosuppressants

3. PT

Front 19

What are the ssx of sarcoidosis?

Back 19

1. Systemic granulomatous disorder

2. Erythema nodosum

3. Lupus vernio

4. Anterior uveitis

Front 20

What is the MC manifestation of sarcoidosis?

Back 20

1. Lung disease---- potato nodes= bilateral hillier LAD

Front 21

What are the ssx of Lofgren's syndrome?

Back 21

1. Erythema nodosum

2. Bilateral hilar LAD

3. Polyarthralgias

Front 22

How do you tx sarcoidosis?

Back 22

1. Steroids

2. Hydroxychloroquine

Front 23

What are the ssx of Peutz-Jegher syndrome?

Back 23

1. AD

2. Perioral melanotic freckles

3. GI polyps

4. Abdominal pain

Front 24

What are the ssx of Gardner syndrome?

Back 24

1. AD

2. Epidermal inclusion cysts, osteomas, lipomas, fibromas

3. Intestinal polyposis

Front 25

How do you tx Gardner syndrome?

Back 25

1. Total colectomy

Front 26

What are the ssx of Osler-Weber-Rendu disease?

Back 26

1. Mat-like tufts of telangiectasias

2. GI bleeding

Front 27

How do you tx Osler-Weber-Rendu disease?

Back 27

1. Blood replacement

2. Fe supplementation

Front 28

How do you differentiate CREST from Osler-Weber-Rendu disease?

Back 28

1. No anti-centromere Abs

Front 29

What are the ssx of IBD?

Back 29

1. Aphthous ulcers during exacerbations

2. Polyarteritis nodosa

3. Pellagra

4. Pyoderma gangrenosum

Front 30

What are the ssx of celiac disease?

Back 30

1. Dermatitis herpetiformis--- excoriations, pruritus

Front 31

What are the ssx of porphyria cutanea tarda?

Back 31

1. Vesicles and bullae on sun-exposed areas

2. Atrophic scarring

3. Milia

4. Facial hypertrichosis

Front 32

What are the ssx of liver cirrhosis?

Back 32

1. Spider angiomas

2. Palmar erythema

3. Jaundice

4. Gynecomastia

Front 33

What are the ssx of hypothyroidism?

Back 33

1. Loss of lateral eyebrows

2. Cold, thick, dry skin

Front 34

What are the ssx of hyperthyroidism?

Back 34

1. Pretibial myxedema

2. Hyperhidrosis

3. Hair loss

4. Exophtalmos

Front 35

What are the ssx of acanthuses nigricans?

Back 35

1. Velvety dark skin

2. Adenocarcinoma of GI

Front 36

What are the ssx of necrobiosis lipoidica diabeticorum?

Back 36

1. Red-yellow waxy atrophic plaques

2. Due to microangiopathy

Front 37

How do you tx necrobiosis lipoidica diabeticorum?

Back 37

1. Calcineurin inh

2. IL steroids

3. PUVA

Front 38

What are the ssx of candidal intertrigo?

Back 38

1. Erythematous, well-demarcated lesions

2. Tendency to fissure

Front 39

What are the ssx Cushing?

Back 39

1. Central obesity

2. Striae

3. Hypertrichosis

4. Facial acne

5. Moon facies

6. Buffalo hump

Front 40

What are the ssx of NF1?

Back 40

1. Cafe-au-lait macule

2. Axillary/inguinal freckles=pathognomonic

Front 41

What malignancies are associated with NF1?

Back 41

1. CML

Front 42

What are the ssx of Ehlers-Danlos syndrome?

Back 42

1. AD

2. Bruising, rupture of blood vessels and viscera

3. Thin, excessively stretchable skin

4. AA subluxation

Front 43

What are the ssx of Marfan's syndrome?

Back 43

1. Abnormal elastic tissue in fibrillin I and II

2. AAA, dissection

3. Striae

4. Herniations

5. Marfanoid habitus