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20 Cards in this Set
- Front
- Back
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Discuss life cycle of Chlamydia
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-elementary body (infectious stage) enters cytoplasm of host cell (intracellular) and forms reticulate body -undergoes binary fission, reorganizes into EBs |
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How is this different from bacteria?
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-no gram stain rxn
-unique cell wall, so penicillin and cephalosporins have no activity |
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What is the etiologic agent of STIs?
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C. trachomatis
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What is the epidemiology of chlamydia?
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-most frequently reported STD (3 mill/yr)
-more common in women -prevalent in youth detention facilities, family planning clinics, national job training recruits |
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What are the risk factors of chlamydia?
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-adolescence
-new/multiple sex partners -history of STDs/presence of another STD -oral contraceptive users -Lack of barrier conraception |
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What is chlamydia commonly seen with?
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Gonnorrhea
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Chlamydia transmission:
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-sexual or vertical, highly transmissible
-significantly asymptomatic, re-infection common -perinatal transmission |
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List 3 local infections in men from chlamydia
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1. Conjunctivitis: majority asymptomatic, mucoid or clear discharge, dysuria
2. Urethritis 3. Prostatitis |
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List 2 complications in men from chlamydia
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1. Reiter's syndrome: rare in women
2. Epididymitis |
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List 2 rare sequelae in men from chlamydia
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1. chronic arthritis
2. infertility |
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List 4 local infections form chlamydia in women
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1. conjuctivitis
2. urethritis: majority asympt., dysuria, pyuria, frequency 3. cervicitis: majority asympt., discharge 4. proctitis |
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List 4 complications in women from chlamydia
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1.endometritis(pelvic infl. disease)
2. Salpingitis(pelvic infl. disease) 3. Perihepatitis (Fitz-hugh-curtis syndrome) 4. Reiter's syndrome |
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List 4 sequelae in women with chlamydia
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1. infertility
2. ectopic pregnancy 3. chronic pelvic pain 4. chronic arthritis (rare) |
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List 4 local infections in infants w/ chlamydia
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1. conjunctivitis
2. pneumonitis 3. pharyngitis 4. rhinitis |
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List one possible complication in infants w/ chlamydia
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1. chronic lung disease
(rare to have sequelae) |
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How is chlamydia tested?
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Culture: urethral swab for men, cervical swab for women, urine for both
Nonculture: NAAT: amplify and detect organism- most sensitive but get false pos.), serology |
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Culture sensitivity and use
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-variable sensitivity 50-80%
-high specificity -used in legal investigations -not suitable for widespread screenings |
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Why is it important to screen for chlamydia?
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-mostly asymptomatic
-can reduce incidence by 50% -reduce transmission and prevalence in population |
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Screening recommendations for chlamydia
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Non-pregnant women: -sexually active under 25 screen annually, over 25 screen if risk factors are present. If infected, screen 3-4 months after treatment
Pregnant women: screen at first prenatal visit and again at 3rd trimester if under 25 |
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Virulence factors |
-unique cell wall |
