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31 Cards in this Set
- Front
- Back
How to assess weight gain in the newborn? |
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What is failure to thrive? |
Poor weight gain by infants and young children is labeled "lack of physiologic growth anddevelopment," but is commonly called "failure to thrive" (FTT). The term FTT will be used for therest of the discussion. |
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When does FTT occur? |
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Conditions can result in FTT. List some. |
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Organic FTT |
Organic FTT is diagnosed when growth failure is causedby an acute or chronic disorder that results in inadequatenutrient intake, malabsorption of nutrients, or increasedenergy requirements.
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Common causes of organic FTT |
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Non organic FTT |
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Causes of Non-organic FTT |
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caloric requirements of infants? |
100-110 cal/kg/day in first 4 months of life |
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Normal RBC values for infants? |
The mean value for hemoglobin for healthy full-term 2-month-old infants is 11.2 g/dL (112g/L), an anticipated drop from the mean hemoglobin at birth of 16.5 g/dL (165 g/L). |
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Physiologic anemia? |
The decrease in hemoglobin occurs because fetal RBCs have a short half-life that leads to a"physiological nadir" for hemoglobin, sometimes also called "physiological anemia." |
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When is the bone marrow stimulated to produce new RBCs? |
110 g/L at 7-9 weeks |
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Causes of anemia in infants? |
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CF inheritance pattern? |
autosomal recessive . For an infant to have the disease, both parentsmust be heterozygote carriers of the mutant allele. Each child of this couple have will have a 25%chance of having CF, a 25% chance of being unaffected, and a 50% chance of being a carrier likehis parents. |
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Genetic counselling for CF? |
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How to ID individuals with CF? |
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Who is on the time for children with cystic fibrosis? |
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Questions to ask about feeding in infants? |
Ask about breast feeding versus bottle feeding and whether the infant has been fed by one orthe other means-or both-since birth.If breastfeeding, how long does the baby feed at a time and does he feed on both breasts?Does his mother have adequate breast milk, and does she eat a healthy diet and drink plentyof fluids?If the baby is bottle-fed, is the formula prepackaged or prepared?How does she prepare the formula and how much water does she add?Has the formula recently been changed?
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How to help parents/caregivers make informed decisions? |
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What is the DDx for organic failure to thrive |
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CHF |
CHF is important to consider in any child with FTT.Difficulty feeding and respiratory distress would commonly be described.
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Formula allergy |
True milk-protein allergy is difficult to diagnose, but typically causesintestinal blood loss (may be gross or occult).These children may also have fussiness, particularly after feeds andvomiting.
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Gastroenteritis |
Gastroenteritis may cause FTT, but is typically associated with bothvomiting and diarrhea and may also be associated with fever and/orbloody stools
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Hypothyroidism |
Hypothyroidism may cause FTT in a young infant.Infants with hypothyroidism tend to have poor feeding and constipationrather than eager feeding and increased stools.
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Malabsorption |
A history of poor weight gain in the setting of good caloric intake and thepresence of loose stools is concerning for malabsorption.
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Tools for screening studies for FTT |
CBC urinalysis Bun/cr |
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What is the sweat chloride test? |
used to diagnose CF sens: 99% spec: 90% false positives can occur |
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Newborn screening for CF? |
detects immunoreactivetrypsinogen in blood, with confirmatory tests done to make the final diagnosis.
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When is genetic typing done for CF? |
f genetic testing is not done as part of the diagnostic workup, most CF experts now recommendgenotyping of patients with CF in order to identify their specific mutations.Although gene therapy for CF is not yet a reality, there are studies currently evaluating not onlygene therapy but also medications that address specific mutations in CF.
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Managing CF? |
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Improved outcomes for CF? |
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