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8 Cards in this Set
- Front
- Back
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What does it mean if a drug is easily displaced from albumin?
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- it will have more of an effect than what was orginally thought b/c when a drug is bound to albumin it isn't active but when it is free it is active = overdose sx.
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Does Albumin bind to hydrophobic or hydrophilic drugs?
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Hydrophobic
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What does it mean if a drug induces P450?
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it increases the rate of metabolism of anything that is metabolised by P450
- the end result is less pharmacologically active drug |
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What reactive with P450 would cause more drug to be active in the body than expected?
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- if the drug inhibited P450 it would dec the metabolism and more would be available in the body
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What are the drugs that can easily be removed from the albumin? Serum Proteins Can Spew.
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Serum Proteins Can Spew:
S - Sulfonamides P - Phenylbutazone C - Coumadin S - Sulfonylureas These drugs tend to be more active with polypharm. |
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What are some examples of drugs that induce P450? One Pharmaceutical Brings About Rapid Liver Metabolism.
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- Drives the P450 to metabolism drugs more quickly, may find less in the blood.
One Pharmaceutical Brings About Rapid Liver Metabolism. O - OCP (Oral Contraceptives) P - Phenytoin B - Barbiturates A - Alcohol R - Rifampin L - Levodopa M - Methadone |
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What are some drugs that inhibit P450s? Some Pharmaceutical Classes Inhibit Drug Catabolism.
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- Inhibiting P450s, so more of the drug would be available in the body
Some Pharmaceutical Classes Inhibit Drug Catabolism. S - Sulfonamides P - Phentylbutazone C - Chloramphenicol I - Isoniazid D - Dicumarol C - Cimetidine |
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What are some drugs that compete with Renal Transporters? Some Pharmaceuticals Plus Urate Stop Transporters.
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Some Pharmaceuticals Plus Urate Stop Transporters.
S - Sulfonamides P - Probenecid P - Penicillin U - Urate (uric acid) S - Salicylates T - Thiazides |
