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15 Cards in this Set

  • Front
  • Back
cholinesterase inhibitors (reverse inhibitors)
used for moderate duration and treats myasenthia gravis, alzheimers, and parkinson's
cholinesterase inhibitors (irreversible inhibitors)
echothiophate (Phospholine Iodide) used for long duration and treats glaucoma

pralidoxime (2-PAM) is used to reverse the effect of echothiophate
cholinesterase inhibitor
prototype: neostigmine (Prostigmin)
ambenonium (Mytealase)
cholinesterase inhibitor
pyridostigmine (Mestinon)
cholinesterase inhibitor
edrophomium (Tensilon)
cholinesterase inhibitor
cholinesterase inhibitor MOA
inhibits cholineserase form inactivating acetylcholine, thereby increasing amount of Ach available at receptor sites
neostigmine uses
treats myasenthia gravis, reversal of nondepolarizing neuromuscular blocking agents
treatment of myasenthia gravis
treatment of myasenthia gravis, reversal of nondepolarizing neuromuscular blocking agents
diagnosis of myasenthia gravis
reversal of ND neuromuscular blocking agents
cholineserase inhibitors adverse
excessive muscarine stimulation as evidenced by increased GI motility, secretions
bradycardia, and urinary urgency
adverse effects may be treated with atropine

cholinergic crisis- can be treated with atropine
provide ventilary support
cholinesterase inhibitors contraindications
obstruction of GI and renal
caution in seizure disorders, hyperthyroidism, PUD, asthma, bradycardia, hypotension
cholinesterase inhibitors interactions
atropine counteracts neostigmine

neostigmine reverses neuromuscular blockade caused by neuromuscular blocking agents after surgical procedures of overdose

succinylcholine- avoid concurrent use
cholinesterase inhibitor effectiveness
fewer episodes of fatigue
improvement in strength of chewing, swallowing, and performing ADLs