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187 Cards in this Set

  • Front
  • Back
Three types of cell junctions
Tight (keeps fluid from entering between cells)
Desmosome (Spot Welding--Holds cells together)
Gap junction (Allows for chemical communication)
Four main types of tissues:
Nervous Tissue
Connective Tissue
Muscle Tissue
Epithelial Tissue
Functions of Epithelial Tissue/Locations in body
Protects exposed surfaces/lines cavities, absorbs/secretes (Ex. Kidney tubules)

Found on skin surface, lining of digestive tract, respiratory, urinary, and reproductive tract
Characteristics of Epithelial Tissues
Tightly packed cells (little intracellular space),
Avascular (no blood cells),
Free surface,
Basement membrane (attaches epithelial to connective tissues beneath),
Regeneration
Nerve supply
How are epithelial cells classified?
By Layers (Simple--1, Stratified--more than 1)
By Shape (Squamous, Cuboidal, Columnar)
Simple Squamous Tissue--Function, Location, appearance?
Absorption/secretion, reduces friction, vessel permeability

Found in heart & blood vessels, kidney tubules

Similar to "jig saw" puzzles in appearance, flat, long, one-layer, thin.
Endothelium
Type of Epithelial tissue--found in inner surface of heart and blood vessels.
Mesothelium
Second type of epithelial tissue found in ventral cavity (superficial layers of protective tissues in ventral cavity)
Simple Cuboidal Tissue--Appearance, Function, Location?
Resembles square, hexagonal boxes

Limited protection for areas of secretion/absorption

Found in Kidney tubules
Simple columnar Tissue--Appearance, Function, Location?
Tall, rectangular in shape

Protects against chemical stress

Found in stomach, Intestines
Stratified Squamous Tissue--Appearance, Function, Location?
Multiple layers of cells--cells can be different shapes (classified by shape of cells on superficial most layer)

Protects from chemicals/friction

Located in mouth/anus
Transitional Tissue--Appearance, Function, Location
Flexibility, allows for stretching/coiling without damage

Located in bladder
Pseudostratified Tissue--Appearance, Location, Function?
Looks like more than one layer but every cell touches the basement membrane, not all cells tall enough to make it to the top

Located in nasal cavity, trachea, bronchi

Protection/secretion, moves mucus w/ cilia
Difference b/t endocrine & exocrine?
Endocrine secretes hormones internally, exocrine excretes hormones outside body
Glandular tissue is also what type of tissue?
Epithelial tissue
Examples of Multicellular exocrine glands
holocrine--sebaceous glands-superficial gland cells burst

merocrine--Mucus-secretory vesicles discharged at surface by exocytosis

apocrine--mammary glands-includes inclusions, secretory vesicles, cytoplasmic components
How are connective and epithelial tissues different?
Epithelial--tightly packed, basement membrane, always faces free surface

Connective--Loosely scattered, no basement membrane, no free surface
Functions of connective tissues:
Bind together and support, protect, energy storage, transport
What is a matrix?
Any & all material in between the cells--matrix often determines function of the cell.
Ground substance
Makes up matrix--binds cells together and determines function

Varies from tissue to tissue ( can be solid or liquid)
Types of fibers:
produced by fibroblasts

collagen fiber (tough, flexible)
Elastic fiber (elasticity & strength)
reticular fiber (networking fibers)
What is matrix made up of??
Ground substance + fibers
Characteristics of Connective tissues
Has nerve supply (except for cartilage)
No free surface,
Many types of cells,
Scattered cells
Types of cells in connective tissue:
Fibroblasts (makes fiber)

Macrophages (eat away bacteria/damaged cells)

Mast cells (contains histamines/heparins to stimulate inflammation)

Adipocytes (fat cells-store fat)
Mesenchyme
Embryonic connective tissue (can differentiate into other connective tissue cells)
Areolar connective tissue
Located around blood vessels, mucus membranes--serves as "loose padding"

characteristics: Scattered cells,
matrix=ground substance (Hyaluronic acid) + fibers (collagen)
Adipose Tissue
Located in subcutaneous tissue, around organs (white and brown fat--white: 1 triglyceride droplet, brown: several droplets) prevents loss of heat and is energy storage.

Characteristics: scattered cells (Adipocytes), Matrix= ground substance (Hyaluronic Acid) + fibers (Collagen/elastin)
Reticular connective tissue
Located in lymph nodes & spleen, forms a framework in tissue

Characteristics: Scattered cells (fibroblasts--reticular cells)
Matrix= Ground substance (hyaluronic acid) + fibers (collagen)
Dense regular connective tissue
located in tendons & ligaments, allows for strength in one direction & extension/recoil.

Characteristics: Scattered cells (Fibroblasts),
Matrix= Ground substance (Very little) + fibers (Collagen)
Dense irregular connective tissue
Located in valves of heart, dermis, periosteum--gives skin its strength, strengthens and supports areas that receive stress from many directions.

Characteristics: Scattered cells (Fibroblasts)
Matrix= Ground substance (hyaluronic acid) + fibers (Collagen fibers)
Elastic connective tissue
Artery walls, elastic ligaments b/t vertebrae, gives stretch and support

Characteristics: Scattered cells, Matrix= Ground substance + fibers
Cartilage--what makes it unique?
Tissues that's resistant to stress.

Has no blood vessels or nerve supply, so gets nutrients by diffusion from matrix, also very slow to heal.
What is the most common type of cartilage?
Hyaline cartilage
Types of Cartilage:
Hyaline, Fibrous, Elastic
Hyaline cartilage
located in nose, trachea, costal cartilage, embryonic skeleton,articular cartilage (ends of long bones) Provides cushioning (strong but flexible)

Characteristics: Scattered cells (chondrocytes in lacunae)
, matrix= Ground substance (chondroitin/Glucosamine) + Fibers (Collagen)
Fibrous cartilage
Located in menisci of knee, intervertebral discs symphysis pubis--provides strength & durability

Characteristics:
Scattered cells (chondrocytes)
Matrix= Ground substances (Little ground substance) + fibers (collagen fibers)
Elastic Cartilage
(Location, Characteristics, Function)
Located in auricle (ear), epiglottis
Provides flexibility

Characteristics:
Scattered cells (Chondrocytes in Lacunae)

Matrix= Ground substance + fibers (collagen)
Osseous tissue
Located in shaft of long bones & outside portions of flat bones--provides strength & durability
Spongy bone
Located in ends of long bones & middle of flat bones--provides support, though not as strong as compact bone , produces red blood cells in spaces.

Characteristics:
Scattered cells
Matrix= Ground substance + fibers
two types of fluid connective tissue:
blood & lymph
Blood
Located in blood vessels, carries nutrients & waste products, important for immunity

Characteristics:
Scattered cells
Matrix= Ground substance + fibers (none unless clots)
lymph
Liquid connective tissue that is found in lymph vessels, important for immunity, carries away excess interstitial fluid

Characteristics:
Scattered cells
Matrix= Ground substance + fibers
The proximal end of Metatarsal I articulates with which bone?
The medial cuneiform
The proximal end of Metatarsal II articulates with ____.
Intermediate cuneiform
The proximal end of Metatarsal III articulates with which bone?
Lateral cuneiform
The proximal ends of Metatarsals IV & V articulate with which bone?
Cuboid
Which tissues do not have blood vessels?
Cartilage (all types), Epithelial tissue
Which tissues do not have fibers?
Blood, lymph
Three types of muscle tissue:
Function of muscle tissues
Skeletal, Smooth, Cardiac

Contains proteins that can shorten & stretch.
Skeletal muscle

(Location, characteristics--regeneration/# of nuclei, striated/non-striated, voluntary/involuntary,etc., function)
Attached to bones via tendons

Tissues has striations, long cylindrical cells (length of bone), multinucleated, limited capacity for regeneration

Voluntary movement of the skeleton (generates heat), posture
Cardiac Muscle Tissue

(Location, Characteristics--regeneration/# of nuclei, striated/non-striated, voluntary/involuntary,etc., Function)
Branched, striated, cells, connected by intercalated discs--Gap junctions/desmosomes, typically one nucleus in cells

Located in heart

Involuntary movement of heart, pumps blood
Smooth muscle tissue

(Location, Function, Characteristics--regeneration, # of nuclei, voluntary/involuntary, striations, striated/non-striated, etc.)
Located in internal organs,
Shape: Banana
Involuntary movement
One nucleus per cell
good capacity for regeneration

Relaxation/contraction helps regulate blood pressure, movement food/urine, etc.
Which connective tissue generally makes up membrane?
Areolar Tissue
What is a membrane?
Protective layer--Epithelium + connective tissue beneath makes up membrane
Serous Membrane
Serous membrane= epitheliuem (Simple Squamous/mesothelium + Areolar/Adipose)

Makes up Periosteum, pericardium, pleura.
Synovial Membrane
Epithelium (Only scattered epithelial cells) + connective tissue (areolar/adipose)

Located in joints, secretes synovial fluid for lubrication
Mucus membrane
Epithelium (Varies--all have Goblet cells) + Connective Tissue (Areolar--Lamina Propria)

Found in Systems with opening to outside (Respiratory, reproductive, digestive, etc.)

Secretes fluid (goblet cells)
Cutaneous Membrane
Epithelium (Stratified epithelium) + Areolar

Found in skin--Protects against friction/abrasion
Parenchymal Cells
Stromal Cells
Functional cells--helps regeneration of tissue

Stromal Cells--Connective tissue cells--leads to collagen scar (Fibrosis)
Nervous Tissue
Conducts nerve impulses--two types of cells--neuroglia & neurons
Neuroglia/Neurons
Neurons--Conduct nerve impulses
(Do not undergo mitosis)

Neuroglia--Supportive cells of Neurons (mitosis)
From which cells in nervous tissue do brain tumors arise?
Neuroglia
Steps in tissue repair:
Inflammation (redness, swelling, pain)--indicator that repair taking place @ site of injury

Granulation (Growth of blood vessels, fibroblasts, mesechyme cells)

Maturation phase--repair (parenchymal or stromal)
Factors that affect tissue repair:
Blood circulation (better circulation=better repair)

Age/metabolic rate

Nutrition (C=collagen, D=Calcium, E=prevent scarring)
Functions of skin:
Synthesis of Vitamin D
Temperature regulation (sweating)
Excretion (sweat, salts, etc.)
Protection (keratinized stratified squamous epithelium
Receptors (merkel cells)
Stores lipids
Keratin/Keratinocytes
Fibrous, structural protein--comprises hair, skin, nails.

Keratinocytes produce keratin
Name types of cells in skin:
Keratinocytes, Melanocytes, merkel cells, Langerhan cells
Melanocytes (function/location)
Produces melanin--located in basal layer of epidermis
Merkel cells (function/location)
Receptor cells for touch, etc--located in epidermis
Langerhan cells (function/location)
Eat bacteria--located in epidermis
Two layers of edpidermis:
Stratum Basale/Sratum Corneum
Stratum Basale:
Basal Layer--cells (keratinocytes) dividing rapidly to migrate superficially and constantly replace top layer of keratinized cells.
Stratum Corneum:
Most superficial layer of skin--dead, keratinized cells with no nuclei. Serves as protection for live cells underneath.
Two regions of Dermis:
Reticular/Papillary
Papillary region:
Contains areolar connective tissue
Reticular region:
Contains Dense irregular tissue (gives dermis, strength, elasticity, extensibility
Dermal Papillae
Small extensions of dermis into epidermis (forms finger/foot prints)
contains blood vessels that nourish hair follicles and lower layer epithelial cells
What is the hypodermis--is it apart of skin?
Subcutaneous tissue (areolar/adipose), not apart of skin
What is a freckle? Nevi?
Concentrations of melanin in skin
What is vitiligo? Albinism?
Partial loss of pigment in certain areas of skin (patches) due to melanocytes in select areas of skin not producing melanin.

Total or partial loss of pigment due to absence or defect in enzyme involved in melanin production.
hemoglobin--oxygenated vs. Deoxygenated?
Oxygenated=bright red in color

Deoxygenated= bluish in color
What is cyanosis?
Appearance of bluish/purple coloration on skin due to tissues near surface being low on oxygen.
What would carotene give to your skin?
Orange/deep yellow hue
Parts of hair:
Shaft, follicle (w/ papilla), root
Hair matrix
Cell division occurs to form structure of hair
Hair papilla
Provides nourishment of hair root
Hair plexus
Groups nerve fiber endings--forms network around hair follicle and is receptor (sends nervous impulses to brain when hair moves)
What gives hair its color?
Melanin
Arrector Pili muscles
smooth muscle attached to hair follicle--contracts to make hair follicle more vertical (stand on end)
Where do sebaceous oil glands open into? What do they make? Where located?
Hair follicle--produces sebum (inhibits bacterial growth)

Skin (except palms, soles of feet)
What hormone stimulates sebaceous glands?
Androgens
Sudoriferous Glands
Water/excretory products
merocrine/apocrine secretions
Ceruminous Glands
modified sweat glands--
cerumen-sticky waxy substance (ear wax)
(Apocrine gland)
Why do nails appear pink? What is their clinical significance?
B/c of underlying capillaries in nail bed/
Protects phalanges/digitals and surrounding soft tissues from injuries
Keloid
Scar (collagen) result of overgrowth of tissue @ site of injury
Basal cell carcinoma
Remains localized (cancer of cells of Stratum Basale) rarely metastasizes or causes death, most common.
Squamous cell carcinoma
Cancer of superficial layer--squamous epithelium, second most common, can be deadly if spreads.
Melanoma
Cancer of melanocytes--one of most dangerous forms of skin cancer, causing most deaths.
First-third degree burns:
First--Epidermis only affected
Second--Epidermis/part of dermis
Third--Epidermis & entire dermis
Why are third degree burns not painful? What are two dangers of these types of burns?
Nerves damaged/burned away, so no sensation of pain

Nerve damage and Loss of skin could lead to further infection.
Functions of Bone:
Mineral Storage (calcium, magnesium, phosphate)

Support of other organs/tissues--protection

Makes blood cells
Red marrow
Located in Epiphyses of bone--makes all blood cells (red, white, platelets)
Yellow Marrow
Fat storage--found in diaphysis of bone
Two parts of bone made up of hyaline cartilage:
Articular cartilage/Epiphyseal plate
Function of Epiphyseal plate:
Allows bones to grow lengthwise (only present in children)
What remains after epiphyseal plate disappears?
Epiphyseal Line
What is found in medullary cavity? Where is medullary cavity found?
Yellow Marrow (fat)/ Middle of bone shaft
2 Layers of Periosteum:
Fibrous layer/ Osteogenic layer
Firbous layer (Periosteum)
Dense irregular connective tissue--allows muscle to attach to bone
Osteogenic layer (Periosteum)
Bone cells for new growth and breakdown
Sharpey's fibers
Matrix of connective tissue (allows periosteum to attach to bone)
What are ligaments/tendons & how do they attach?
Fibrous Dense regular connective tissue:

Ligaments (attach bone to bone)

Tendons (attach muscles to bone)
Bones of Os coxa:
Ilium, ischium, pelvis
Which tendon inserts in Calcaneus?
Achilles Tendon
Ground substance/Fibers of bone:
Ground Substance = Chondroitin/Glucosamine

Fibers= Collagen
Organic part of Bone matrix--what characteristic does it give to bone?
Collagen--makes bones more flexible, elastic
What characteristic do calcium salts give to bone?
Hardness
Scattered cells of bone:
Osteoprogenitor cells (endosteum periosteum), osteoblasts, osteoclasts, osteocytes
Which scattered cell of bone is not derived from mesenchyme?
Osteoclasts (derived from white blood cells)
Two types of bone:
Compact/spongy
Where is compact bone found?
Diaphysis
Where is spongy bone found?
Epiphyses
How do osteocytes in spongy bone get their nourishment?
Directly from bone marrow
What are trabeculae?
supporting bundles fiber formed by matrix (small extensions bone)
How is spongy bone different from compact?
compact needs osteons , spongy uses trabeculae for nourishment
Haversian Canal
surrounds blood vessels, communciates w/ osteocytes in lacuna
Appositional growth
Growth on surface of tissue (bone/cartilage)
Interstitial growth
Growth within tissue (cartilage)
Can you see cartilage on an xray?
No, shows up as "space" between the bone
Where does bone growth in length occur?
At epiphyseal plate
Where does bone growth in width occur?
At endosteum/periosteum
Ossification
Process of bone formation
Intramembranous ossification
Examples:
bone formation from fibrous connective tissue
Ex. Clavicle, mandible, cranium
Endochondral ossification
bone formation from hyaline cartilage
Ex. Long bones, embryonic skeleton
Process of intramembranous ossification:
Beings @ ossification center (mesenchyme turns to osteoprogenitor to osteoblasts)

Osteoblasts secrete matrix, become osteocytes

Trabeculae develop, red bone marrow fills spaces

Spongy bone later remodels to compact bones
Process of endochondral ossification
bone collar on surface of diaphysis

cells die in diaphysis (ph change/calcification)

blood vessels penetrate and bring in osteoprogenitor cells

Differentiate into osteoblasts that lay down new bone
Primary ossification center
Middle of diaphysis
Secondary ossification center
middle of epiphyses
Which type of bone is always formed first when bone is made?
Spongy bone (later remodeled into compact bone)
Functions of calcium
Nerve impulses, muscle, contraction, bone health
Calcitonin
Lowers blood calcium by depositing it into bone (osteoblasts)
Parathyroid hormone
Raises blood calcium by taking it from bone (osteoclasts)
Steps in bone repair
Hematoma (blood clot)
Hyaline cartilage callus
Spongy bone callus
Remodeled into hard bone (bony callus remains)
Colles fracture/Greenstick fracture:
Colles fracture--fracture of distal radius (falling on outstretched arm)

Greenstick fracture (occurs in children) one side of bone breaks and other side of same bone bends--due to flexibility of child bones.
Axial skeleton
(Trunk) consists of head/neck, spine (vertebrae), rib cage, sacrum, coccyx, hyoid
Appendicular Skeleton
(Appendages) consists of arms, clavicle and shoulder girdle scapula), legs, knee, ankle, wrists, os coxae,
Shapes of bones
Flat, irregular, Long, short
Examples of long bones
Ulna, Radius, Humerus, Femur, Tibia, Fibula
Examples of short bones
metacarpals, carpal bones, metatarsal and tarsal bones
Examples irregular bones
Vertebral bones
Examples of Flat bones
Cranial bones, os coxae, sternum, ribs, scapula, clavicle
8 Cranial bones
2 parietal, 2 temporal, frontal, occipital, sphenoid, ethmoid
Wormian bones
Extra bone pieces in cranial sutures
Sesamoid bones
Bones that form in tendons--patella, pissiform
What are the articulations of skull bones called?
Sutures
What is a fontanel?
"Soft spot" on the skull of infant where fibrous collagenous tissue remains--skull not completely connected, allows for easier labor/delivery, allows baby's head to mold to fit through birth canal without injury to mother or baby.
14 Facial bones
2 maxillae, mandible, vomer, 2 zygomatic, frontal, 2 nasal, 2 lacrimal, 2 inferior nasal conchae
Which two bones form hard palate?
Maxillae and palatine
Which two bones have aveolar processes for teeth?
mandible/maxillae
Which facial bones form only movable joint on face?
Mandible and Temporal Bones (Temporomandibular joint)
What is the purpose of a sinus?
Make skull more light weight--contains mucus membrane in sinus cavities (filters air that goes through sinuses)
4 bones in which sinuses can be found:
Zygomatic, maxillae, ethmoid, frontal
Where do sinuses drain into?
Into nose through middle meatus
What are nasal conchae and what is their function? How many are there?
Small bones that extend into nose, directs air towards mucus membranes.
3 nasal conchae (Superior, middle, inferior)
What are two parts that make up intervertebral dics:
Fibrocartilage ring
Nucleus Pulposus (Gel pad in middle of disc)
What is a herniated disc?
Nucleus pulposus protrudes out of fibrocartilage disc.
What are primary/secondary curves?
Primary= curves that stay as originally shaped (Thoracic/sacral)

Secondary= anteriorly convex--develops as child devleops
(Lumbar/Cervical)
What are abnormal curves--three types?
Kyphosis--Exaggerated thoracic curves
Lordosis--Exaggerated Lumbar curves
Scoliosis--Spine curved sideways
Intervertebral foramen
Opening in vertebrae where nerves leave spine and extend to other parts of body
Vertebral foramen
Opening formed by union of vertebral arch w/ body
How many cervical vertebrae are there?
Thoracic? Lumbar?
7, 12, 5
What is the name of C1? C2?
Atlas/Axis
Which group of vertebrae are most susceptible to herniated discs?
Lumbar (Lower back--more stress pressure)
How are the os coxae connected to the vertebral column?
By the sacrum
What does the superior surface of L5 form a joint with? Inferior surface?
w/ L4
w/ Sacrum
Difference between true & false ribs?
True attach to sternum by their own costal cartilage

False attach to the costal cartilage of true ribs
Costal cartilage
Connects sternum with ends of ribs
To which two bones are the ribs attached?
Sternum, vertebral column
Three parts of sternum:
Xiphoid process
Manubrium (sternal angle, Jugular notch)
Body
How does the sternum attach to the appendicular skeleton?
By the clavicle
Which two bones does scapula form a joint with?
Humerus & clavicle
Does scapula form a joint with ribs?
No
8 carpal bones:
Scaphoid, Lunate, Trapzium, Pissiform, Triquetrum, Trapezoid, Capitate, Hamate
How many total phalanges in one hand?
14
"Medial" ankle bones is actually which bone?
Tibia--medial malleolus
Six bones of tarsus?
Talus, Navicular, Intermediate Cuneiform, Medial cuneiform, Lateral Cuneiform, Cuboid
What is hallux, pollex?
Big toe, Thumb