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13 Cards in this Set
- Front
- Back
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Cell cycle control system |
A cyclically operating set of molecules in the cell that triggers and coordinates key events in the cell cycle. |
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Checkpoint |
A critical control point in the cell cycle where stop and go-ahead signals can regulate the cycle. |
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Go Phase |
A nondividing state in which a cell has left the cell cycle. |
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Cyclin |
A regulatory protein whose concentration fluctuates cyclically. |
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Cdks |
A protein kinase that is active only when attached to a particular cyclin. |
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MPF |
Maturation- promoting factor ( M-phase-promoting factor); a protein complex required for a cell to progress from late interphase to mitosis. The active form consists of cyclin and a protein kinase. |
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Growth Factor |
A protein that must be present in the extracellular environment( culture medium or animal body) for the growth and normal development of certain types of cells; a local regulator that acts on nearby cells to stimulate cell proliferation and differentiation. |
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Density-dependent Inhibition |
The phenomenon observed in normal animal cells that causes them to stop dividing when they come into contact with one another. |
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Anchorage Dependence |
The requirement that to divide, a cell must be attached to the substratum. |
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Transformation |
(1) The conversion of a normal animal cell to a cancerous cell. (2) A change in genotype and phenotype due to the assimilation of external DNA by a cell. |
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Bengin Tumor |
A mass of abnormal cells that remains at the site of origin. |
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Malignant Tumor |
A cancerous tumor that is invasive enough to to impair the functions of one or more organs. |
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Metastasis |
The spread of cancer cells to locations distant from their original site. |
