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46 Cards in this Set

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OCD

· Obsessions: wishes, impulses, images, ideas,doubts· Compulsions (behaviors): repetitive, rigidbehaviors, even mental exerciseso Doneto relieve anxiety· Person knows that thoughts come from their ownmind (not like schizophrenia)o Mosthave “insight”· Men and women equally likely to have it· One year prevalence 1%· Appears more in people who are divorced· Begins teens/young adult· Co-morbid with depression


Causes of OCD

o Somegenetics (monozygotic twins are more likely to have it than dizygotic twins)§ This may explain why there is not much of agender differenceo Moreactivity in the orbital frontal cortexo Problemsgetting info from orbital frontal to caudate nucleus to thalamus


Treatment for OCD

o Releaseof serotonin with behaviorso Replacewith SSRIs (60%)o Exposureo Responsepreventiono Mindfulnesso Cingulatebundle lesion – very extreme


Howard Hughes

Had OCD


Spruce Goose - one of the biggest airplanes in the world, never flew


Richest man in the world at one point

Body Dysmorphic Disorder

· They think they are ugly· Suicide· Similar to OCD· Men and women equally likely to have it· Treatment: group therapy and antidepressants· Michael Jackson· 1% general population· 50% major depression· 80% suicidal ideation· 75% unnecessary treatments (surgery)· A disorder of the present· Regulated through serotonin (like OCD)· Universal disorder· “Looks are everything”

Excoriation

Obsessively picks at skin

Response prevention

Make it so they can't do the behaviors

Habit reversal training

Do the opposite of your habit

Most common mood disorder?

Major depressive disorder

Depression

· Symptomso Emotional:miserable, empty, humiliated, no sense of humor, anger, anxiety, crying spells,loss of love for otherso Behavioral:less activity, more time alone, move slowly, no energy, talk slower, less eyecontacto Cognitive:negative views (distorted), guilty (blame themselves), inadequate, helpless,procrastinate, can’t concentrate, ambivalenceo Physical:headaches, dizzy, pain, sleep, eat, tired


What causes postpartum depression?

Change in estrogen levels

What causes Seasonal Affective Disorder?

o Melatonin(hormone of darkness)o Suprachiamaticnucleus


Factors that make fewer new neurons

Stress, sleep deprivation, alcohol

Factors that make more neurons

Prozac, sexual activity (in males), aerobic exercise

4 neuronal truths

Brain makes new neurons


Not most will die


Learning keeps them alive


Must be successful and effortful

Cognitive Behavioral Therapy

Increase activity and elevate mood


Examine and invalidate automatic thoughts


Identify distorted thinking


Alter primary attitudes

New helplessness theory is based on what?

Pessimistic attitude


One or more negative life event


Hoplessness

Behavioral addiction

3rd generation

Skinner


Based on principles of operant conditioning



Rank order things you like to do

Mindfulness

Mindfulness training - 8 weeks


Bigger: left hippocampus, cingulate cortex, and cerebellum

Exercise

Improves mood, increases neurogenesis, increases size of hippocampus, increases BDNF, increases blood volume

What is an SSRI?

Selective serotonin reuptake inhibitors

Electroconvulsive Therapy (ECT)

Developed 1500s


100,000 treated with ECT each year


Administered bilateral (both sides of head) and unilateral


We do not know if it is effective for depression and mania


Makes new neurons (but not in the right direction)

Deep brain stimulation

Stimulates patients' brains electrically


Invasive


Mayberg et al., 2005


Provides relief to patients with depression

Ketamine

Anesthetic at high dose


NMDA receptor antagonist


Long-lasting

Bipolar characteristics

Less than 1% of the population


No sex difference


Onset is sudden


First episode is manic


Between 20-30 years of age


More divorce


Alcoholism


~15% suicide


5x more identical than fraternal

Another name for Bipolar II?

Cyclothymania

Lithium Carbonate

Sodium ion transport


Lithium substitutes for sodium


1949, John Cade


Effective in 80%


Toxic


Impotence and weight gain


Heart and kidney damage


Increases neurogenesis

Anticonvulsants

Depakote/valproic acid; anti-seizure; increases GABA

Antipsychotic

Risperidone; Abilify (less dopamine activity)

Seroquel

Newer type of antipsychotic


Antagonist = blocks receptors


For dopamine, serotonin, norepinephrine

Suicide

40,000 a year in US alone


Most common in 25-44 years old


But increasing most in age 20-24


Most in elderly (>65)


~5-10% schizophrenics


700x in murderers

Schneiderman's 4 suicide types

Death seeker: want to end life


Death initiator: hurrying inevitable


Death ignorer: afterlife


Death darer: toy with idea

Why do people commit suicide?

Genetics


SOME overactive HPA axis (more cortisol)


SOME bigger adrenal glands

Jack Kavorkian

Assisted suicide

Palliative care

Keep someone comfortable, but don't do anything to keep them alive

Dimensions of personality (the big 5)

Extraversion


Conscientiousness


Agreeable


Emotional stability


Openness to experience

Paranoid personality disorder

Suspicious of others


Mistrust


Ideas of reference


Often alone


Don't seek help or quit

Schizoid personality disorder

No social skills


No relationships


Restricted emotions


Similar to negative symptoms of schizophrenia


Like being alone!


Choose to be alone

Schizotypalpersonality disorder

Thinking is bizarre


Eccentric behaviors


Paranoid


Prefer to be alone


More severe than schizoid or paranoid


Very uncomfortable with social settings


No sense of humor


Believe in magic, ESP or horoscopes


Antipsychotic drugs can help

Antisocialpersonality disorder

Criminal behavior


Deceitful and aggressive


More males


More Caucasians


Alcoholics


ADD and conduct disorder


Gene for testosterone receptor


ANS is dampened


Genetic


Lower IQ

Borderlinepersonality disorder

Unstable!


Major shifts in mood


Impulsive


Self-mutilation


Risk of suicide


Fear of abandonment


>75% women


Women get antidepressants


Men get antipsychotics


History of abuse and neglect


DBT

Histrionicpersonality disorder

Excessive emotion


"On stage" - like a lot of attention


Fads


Sexually proactive


More women diagnosed


Seek treatment

Narcissisticpersonality disorder

Grandiose


More self-satisfied than histrionic


Often rude


Narcissus


Hitler


>75% men

Avoidantpersonality disorder

Shy!


Want to be social but fear rejection (as opposed to schizoid)


Sensitive to shame and criticism


Similar to social phobia but longer


Fear relationships


Avoid eye contact


Avoid talking

Dependentpersonality disorder

Common


Clinging


Submissive


Opposite of avoidant


Equal men and women

Obsessive-compulsivepersonality disorder

Everything has to be right


Strict values and moral code


Stingy = miserly


More men


Like OCD but less severe


They like the behavior!


Can't get rid of things


Can't delegate