Essay about Types and Treatment of Sandhoff Disease
The disease was discovered by Konrad Sandhoff (1939- ), a German biologist. Konrad Sadhoff studied the biochemistry of both sphingolipids and gangliosides and in October 1966, he acquired a frozen autopsy substance from a child with amaurotic idiocy. …show more content…
Anybody can be a carrier of Sandhoff disease. When parents are mutual carriers, each child has a 25% of getting the disorder. The carrier rate for the over-all populace is small, around 1/600 and it is still unclear whether Sandhoff disease is more common in any specific populace, but may have a greater carrier rate in more than a few slightly remote populations. Based from medical records, the disease is more common in the Creole populace of northern Argentina, the Metis Indians in Saskatchewan, Canada, and the populace from Lebanon.
There are only three categories of Sandhoff disease—classic infantile, juvenile, and adult late onset. Each form is categorized by the severity of the symptoms and the stage of development at which the patient exhibits these indicators. The three forms are:
• The Classic infantile form of the disorder is