• It was the spread of a disease called smallpox; fights the blood vessels of the human skin which causes pus-filled blisters that are painful
• An African, who was held as a slave, was infected by smallpox realizing he was carried on the Spanish boat
• One of Cortes’ men had been infected by the disease and the infection had scattered throughout the civilization
• Aztecs had no cure or resistance for smallpox
• With barely enough time to burry the bodies, houses had been collapsed on the corpses
• In 1520, the population had two main problems – low on food source and also suffering from smallpox
• 25% of the empire had died from the disease itself; including Cuitláhuac