The Design Of Two Bioanalytical Sensors Essay

2167 Words Oct 18th, 2016 9 Pages
In this proposal, we report the design of two bioanalytical sensors: (1) a fluorescence optrode-based optical fiber sensor and (2) a carbon-based optically transparent electrode. The first provides a means for spatially organizing microorganisms to monitor their social behavior in response to different chemical environments. The electrode sensor enables the detection of signaling molecules that are responsible for, or a consequence of, sociomicrobial behavior. Upon their completion, these sensors will be coupled with a micro three-dimensional printing (µ3DP) technique. These sensors will provide key insights to understanding cellular communication and behavior in organized in vitro microenvironments that closely mimic in vivo settings (Scheme 1).
Recently there has been a rising interest in studying cellular communication and sociomicrobial behavior, which can provide fundamental information about the development of severe infections in host organisms by pathogenic bacteria.1-5 These microorganisms demonstrate highly social behaviors such as the ability to communicate by producing, releasing, detecting and responding to small signaling molecules.6-8 This process termed quorum sensing (QS),9,10 allows a population of bacteria to monitor its environment for the presence of other bacteria and to modulate the population’s behavior in response to the effective density of microbial species present in a neighboring community.6-8 Although there have been significant efforts to…

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