Essay The And Pathophysiology Of Depression

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Depression is a brain disorder which generate major disability. Its etiology and molecular mechanism is not fully understood. It is a leading cause of disability globally, with lifetime prevalence as high as 20% (Kessler et al., 2005). Depression is multifactorial disorders that differ in symptomology and most possibly in etiology. There are various symptoms of depression include depressed mood, mood swing, loss of pleasure activities (anhedonia), inability to concentrate, lack of energy, disturbed sleep or appetite, feelings of worthlessness or guilt, and suicidal ideation and tendencies etc.(DSM-IV)(1994).
Animal models of depression have a function of to replicate some known aspects of depression in preferred animal species (e.g. rodents). On this basis they can be used as an instrument for examining aspects of the neurobiology and pathophysiology of depression. They can be used as experimental models for studying the mechanism of action of antidepressant drugs and as screening tests for revealing antidepressant activity. Antidepressant drugs have slight or no function in healthy individuals. The number of validated animal models for affective disorders is great and still emerging.
Even much has been learned about the neural circuitry of mood on the basis of various studies of brain imaging and a mass of endocrine variations have been illustrated in many individuals of depression, no anomaly has proven satisfactorily powerful enough to either diagnose depression in…

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