Gout Research Paper

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Gout has been known to be a quite painful form of inflammatory arthritis for people who suffer from it. It is entirely possible for any age group, as well as, either gender to have issues with gout. However, generally men over the age of 45 will start to suffer from gout. The beginning of gout usually occurs in the big toe and has obvious symptoms, such as being very sore, red, swollen, and feels warm around the joint. Additionally, gout can eventually affect other regions of body for instance, ankles, heels, knees, wrists, fingers, and elbows. Symptoms in these regions aren’t always continuous, individuals will suffer from what are known as gout attacks. During the attacks, is when the most pain occurs in the areas mentioned previously (Edwards, …show more content…
Phosphoribose is then, synthesized by synthase and is now PRPP (or phosphoribosyl pyrophosphate). The PRPP is then, converted to the nucleotide IMP (or inosine monophosphate). The nucleotide IMP can then, be converted to both purines AMP (or adenosine monophosphate) and GMP (guanine monophosphate). Both purines AMP and GMP are further broken down by xanthine oxidase to make uric acid. However, individuals with hyperuricemia resulting in gout have an overproduction of purines. Therefore, if the purines are continuing to be produced xanthine oxidase continues to break down AMP and GMP into uric acid. The over production of uric acid creates those crystalized deposits in the body (Choi, Mount, & Reginato, 2005, pp. …show more content…
There are other risk factors for gout such as, age particularly individuals over the age of 45. As mentioned before, gender is a key risk factor because more men are affected by gout than women. Ethnicity additionally, is a risk factor for gout, more so in Hispanics and African Americans mostly due to genetic aspects. A high-fructose diet is comparable to a diet high in purines because eating more foods high in fructose can make uric acid levels higher. A few other risk factors include being obese, having a previous joint injury, the use of diuretics or water pills, high blood pressure, heart disease, diabetes, and kidney disease (Edwards,

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