Schiff Bases Case Study

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Schiff Bases:
Schiff bases are amongst the important class of drugs containing imine or azoethine (-C=N-) moiety,have been obtained by the condensation of primary amines and carbonyl compounds.It was first time presented by the Hugo schiff (Cimerman et al, 2000).
Schiff bases are one of the most important class of organic drugs widely used in variety of different fields such as analytical, biological, and inorganic chemistry.The schiff bases heve been designed to synthesize more and more novel lead molecules possessing least toxicity with highest efficacy.Schiff bases have importance since the last decade that it pulled the researchers towards the most appropriate access in forming novel derivatives in medicinal field.(Anu et al, 3013).
Due
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(51) 7-(4-(3-(4-substituted benzylidineamino) phenyl imino)-5-fluoro-2- oxidoline-1 -yl)methyl)piprazine-1-yl-) 1-cyclopropyl-6-fluoro-4-oxo-
1,4-dihydroquinoline-3- carboxylic acid.

schiff bases ligand and their metal complexes with Mn (II),Cu(II),Ni(II), have been synthesized by Pallavi et al, 2014 , and then evaluated for their antimicrobial activity.These compounds were potent and showed significant anti microbial activity.and also in the field of medicinal,organic and in organic chemistry

Anti tubercular
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(54)
4-(1,3-dioxo-1,3-dihydro-2H-isoindole-2-yl)-N (sunstituted phenyl)methylene /ethylidene benzohydrazide
Some novel derivatives of 3-aryl-4(3H)-quinazolinone-2-carboxaldehyde and related schiff bases have been synthesized by Aly et al, 2010.These compounds showed not only anticonvulsant but also analgesic,and cytotoxic potential due to the presence of the side chain of themicarbazone with free amino group and fluorine atom.

Anti Inflammatory and Analgesic Activity:
(Nithinchandra et al, 2012) synthesized Sydnone containing new schiff bases derivatives (compound 55) and then screened for their analgesic and anti inflammatory propetties.Results revealed that these compounds possessing good

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