Essay on Role Of Of In The Management Of Type 2

1143 Words Mar 6th, 2015 5 Pages
Date and time requested: January 21, 2015 at 11:30 AM
Date and time answered: February 28, 2015 at 3:00 PM
Describe the role of Trulicity in the management of type 2 DM. What does the evidence show and its place in therapy?

Background In the United States, approximately 25.8 million people have diabetes. Of the 25.8 million people, about 5% to 10% have type 1 diabetes and 90% to 95% have type 2 diabetes (T2DM).1 The prevalence of diabetes is much higher in non-Hispanic white, American Indian and African American and lower in Hispanic and Asian.1 Majority of the worldwide diabetic patients are type 2 diabetes which means they are insulin resistant. Insulin is important in lowering blood glucose by bringing in glucose inside the cells. If their bodies are resistant to insulin, there will be less glucose going into the cells and more glucose in the blood which indicate a high hemoglobin A1c level (HbA1c).2 HbA1c level above 7% will increase the risk for artery diseases, stroke, diabetic neuropathy, nephropathy, and retinopathy. Therefore, treatments are constantly being developed to lower blood glucose to reduce these micro-vascular and macro-vascular complications in diabetics.1 One of the newly approved treatment for type 2 diabetes is Trulicity (Dulaglutide). It is a long acting glucagon-like peptide-1 receptor agonist (GLP-1 RA) that is administered once weekly by subcutaneous injection.3 Dulaglutide acts like endogenous GLP-1 incretin hormone, resulting in an increase…

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