Rheumatoid arthritis (RA) is a chronic destructive polyarthritis. Disease progression induces the production of lesions on joints, which can cause severe damage that lead to cartilage destruction and bone erosion, and eventually to the loss of joint functions [1, 2]. The synovial fluid and the serum of RA patients contain high levels of proinflammatory cytokines such as interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) [3, 4]. The high levels of TNF-α are produced mainly by macrophages and can induce cartilage degradation and induce antigen-presenting cells triggers TH17 activation in rheumatoid arthritis [5, 6]. TH17 plays an important role in the progress of rheumatoid arthritis, TH17 and Il-17 is known as highly correlated
…show more content…
To understand the different outcomes of MSCs in stem cell therapy, we hypothesized that these differences may be attributed to the existence of distinct subpopulations in the isolated stem cells. During the disease progress, the cartilage degradation is irreversible damage. The intra- articular injection is an effective technique to detect the locally repair of the MSCs[31, 12]. In this study, we predict the stem cells might able to cure the irreversible cartilage damage in arthritis mice. We used the intra- articular injection method to detect the disease progress and joint histological change post CD146+ cells and CD146- cells post IA injection. To the best of our knowledge, this is the first study to show the role of CD146 antigen in the immunomodulatory effects of MSCs. Our results show that CD146 antigen is not only a marker of progenitor cell but also a suppressor of TH17 cells. In addition to these roles, CD146 also plays a role in promoting chondrogenesis. Our data suggests that these cells may have therapeutic potentials in
To understand the different outcomes of MSCs in stem cell therapy, we hypothesized that these differences may be attributed to the existence of distinct subpopulations in the isolated stem cells. During the disease progress, the cartilage degradation is irreversible damage. The intra- articular injection is an effective technique to detect the locally repair of the MSCs[31, 12]. In this study, we predict the stem cells might able to cure the irreversible cartilage damage in arthritis mice. We used the intra- articular injection method to detect the disease progress and joint histological change post CD146+ cells and CD146- cells post IA injection. To the best of our knowledge, this is the first study to show the role of CD146 antigen in the immunomodulatory effects of MSCs. Our results show that CD146 antigen is not only a marker of progenitor cell but also a suppressor of TH17 cells. In addition to these roles, CD146 also plays a role in promoting chondrogenesis. Our data suggests that these cells may have therapeutic potentials in