Recombinant Angiostatin and Endostatin are naturally occurring polypeptides that are found several animal species and in humans. Angiostatin is produced by the cleavage of plasminogen and endostatin is formed by the splitting of collagen XVlll. Its main functions are being endogenous inhibitors of angiogenesis that had been shown to reduce tumours size in murine models. They both are currently still being studied and undergoing clinical trials.
Angiogenesis is defined as the development of new blood vessels by using endothelial cells and it is essential in the healing process and reproduction of organisms. It also causes the growth of tumours to increase in size by surrounding the tumour with blood vessels to give it essential nutrients required to grow. In order to shrink Angiostatin only affects endothelial cells. It is produced to prevent the migration and formation of endothelial cells. Studies with recombinant show that the tumour inhibitory …show more content…
Michael O'Reilly was the first to discover the existence of endostatin and angiostatin. In 1971, Folkman hypothesised that by cutting off the blood supply to tumours, it could shrink the tumour. His theory was disregarded by many scientist because they thought that it was unimportant. He and his team researched for a protein that could block the blood supplied to the tumour. In 1985, blood vessels cells that were cultured in Folkman's lab were contaminated with yeast which contained fumigillin which shows the tumour growth. He also hypothesised that large tumours released inhibitory angiogenesis factors which blocks the blood supply to smaller tumours causing it to shrink. Dr. Michael O'Rielly, a member of Dr.Folkman's team, searched for a substance in mouse blood and discovered angiostatin and endostatin in the urine of a tumour bearing mice. It was then administered into the mice and was effective in shrinking the tumour and it showed no significant side effect in the
Angiogenesis is defined as the development of new blood vessels by using endothelial cells and it is essential in the healing process and reproduction of organisms. It also causes the growth of tumours to increase in size by surrounding the tumour with blood vessels to give it essential nutrients required to grow. In order to shrink Angiostatin only affects endothelial cells. It is produced to prevent the migration and formation of endothelial cells. Studies with recombinant show that the tumour inhibitory …show more content…
Michael O'Reilly was the first to discover the existence of endostatin and angiostatin. In 1971, Folkman hypothesised that by cutting off the blood supply to tumours, it could shrink the tumour. His theory was disregarded by many scientist because they thought that it was unimportant. He and his team researched for a protein that could block the blood supplied to the tumour. In 1985, blood vessels cells that were cultured in Folkman's lab were contaminated with yeast which contained fumigillin which shows the tumour growth. He also hypothesised that large tumours released inhibitory angiogenesis factors which blocks the blood supply to smaller tumours causing it to shrink. Dr. Michael O'Rielly, a member of Dr.Folkman's team, searched for a substance in mouse blood and discovered angiostatin and endostatin in the urine of a tumour bearing mice. It was then administered into the mice and was effective in shrinking the tumour and it showed no significant side effect in the