Outcome of Ventilator-Associated Pneumonia: Impact of Antibiotic Therapy and

3904 Words Apr 16th, 2012 16 Pages
Australasian Medical Journal [AMJ 2012, 5, 2, 135-140]

Outcome of ventilator-associated pneumonia: Impact of antibiotic therapy and other factors
Noyal Mariya Joseph1, Sujatha Sistla1, Tarun Kumar Dutta2, Ashok Shankar Badhe3, Desdemona Rasitha1, Subhash Chandra Parija1 1. Department of Microbiology, 2. Department of Medicine, 3. Department of Anaesthesiology and Critical Care Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry - 605006, India

RESEARCH
Please cite this paper as: Joseph NM, Sistla S, Dutta TK, Badhe AS, Rasitha D, Parija SC. Outcome of ventilatorassociated pneumonia: impact of appropriate therapy and other factors. AMJ 2012, 5, 2, 135-140. http//dx.doi.org/10.4066/AMJ.2012.1004.
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There is a great interest in determining the factors influencing the outcome of VAP, as it may help in reducing the associated morbidity and mortality. This study aimed to determine the impact of appropriate antibiotic therapy based on endotracheal aspirate cultures on the outcome of VAP. We have also studied the other factors that may influence the outcome of VAP. Method A cohort study was conducted in the intensive care units of a tertiary care hospital in South India over a period of 15 months. The outcome of VAP was assessed by prolongation of the duration of mechanical ventilation and/ or death of the patient. Results The duration of mechanical ventilation was significantly prolonged in patients with VAP (16.61 ± 8.2 d vs. 8.21 ± 5.9 d, P < 0.0001). VAP patients receiving partially or totally

Background
Ventilator-associated pneumonia (VAP) is the most frequent intensive-care-unit (ICU)-acquired infection, occurring in patients intubated for longer than 48 hours. It is defined as pneumonia occurring more than 48 hours after the initiation of endotracheal intubation and mechanical 1 ventilation (MV). The incidence of VAP ranges from 6 to 2 52% and can reach 76% in some specific settings. The mortality rates for VAP range from 20% to 76% in various 3,4 studies. In a retrospective matched cohort study using data from a large US inpatient database patients with VAP had a significantly prolonged duration of MV (14.3 days vs. 4.7 days),

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