Summary Of The Most Effective Dose Of Nalbuphine

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AIMS AND OBJECTIVES: To find out the most effective dose of nalbuphine as adjuvant to spinal anaesthesia. To compare the three different doses and find out most optimum dose of nalbuphine with minimal side effects and maximum analgesic effect.
MATERIALS AND METHODS: We conducted prospective randomized double blinded controlled study with 120 ASA I and II patients who were undergoing lowerlimb orthopedic surgery under spinal anaesthesia. We randomly allocated four groups A,B,C to receive 0.4, 0.6,0.8 mg nalbuphine made up to 0.5 ml with distilled water and group D receive 0.5 ml of plain distilled water added to2.5ml of 0.5% hyperbaric bupivacaine (3ml) respectively. The onset of sensory block and motor block, duration of surgery, duration
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Nalbuphine 0,8 mg (group C) have prolonged duration of analgesia (table 2) but increased advere effects ( table 3). As regarding neurotoxicity of intrathecal nalbuphine , it used modern day practice more than 10 yrs without neurotoxicity(14).
Conclusion:
We concluded that intrathecal nalbuphine 0.6 mg added to 0.5% hyperbaric bupivacaine for spinal anaesthesia in patients undergoing lower limb orthopedic surgeries had prolonged duration of motor block and duration of analgesia without increased adverse effects. So we conclude that 0.6 mg of nalbuphine is better adjuvant to bupivacaine in spinal anaesthesia.

References :
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