Linezolid Research Paper

Linezolid, chemically (S)-N-({3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide, a synthetic antibiotic belong to a new category of antimicrobials called the oxazolidinones. Linezolid disrupts bacterial expansion by inhibiting the initiation process in protein synthesis. Distinctively, linezolid binds to a site on the bacterial 23S ribosomal RNA of the 50S subunit and prevents the bargain of a resourceful 70S initiation multifaceted, which is an essential section of the bacterial translation process. The results of time-kill studies have shown linezolid to be bacteriostatic against enterococci and staphylococci. For streptococci, linezolid was found to be bactericidal for the majority of strains. Linezolid is also a reversible, nonselective inhibitor of monoamine oxidase 1-2. Therefore, linezolid has the potential for interaction with adrenergic and serotonergic agents Fig1. …show more content…
The antibacterial consequence possesses a mechanism of action comparable to penicillins i.e. inhibition of transpeptidation course resulting in the arrangement of inadequate cell wall; osmotic impel from the outside isotonic environment of the host cell to the inside of the hypertonic bacterial cytoplasm and finally activation of the autolysin enzyme leading to the lysis of bacteria 3. Cefixime is used to treat positive infection caused by bacteria such as bronchitis (infection of the airway tubes leading to the lungs); gonorrhea (a sexually transmitted disease); and infections of the ears, throat, tonsils, and urinary tract Fig