Haemophilia is a hereditary bleeding disorder that impairs the body’s ability to coagulate or clot blood; it is caused by a deficiency or absence of a specific coagulation factor, usually factor VIII (FVIII) or factor IX (FIX). People with haemophilia will experience longer bleeding after an injury, easy bruising, and spontaneous internal bleeding. As of now, there only on-demand or instantaneous treatments consists of concentrate infusions of the missing factor and aims to improve a patient’s quality of life (Coppolo at al. 2010). However, there have also been recent studies on utilizing gene and cell therapies as forms of treatment for this disorder, and the results have been highly satisfactory. One kind of cell therapy, using induced pluripotent
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Although it has been recognized as a bleeding disorder since the second century, its origins were not discovered until the late 19th century. Haemophilia was known to be a recessive sex-linked disorder as it is carried down generations through the X sex chromosome. Since males have one X and one Y chromosome, if their X chromosome contains the gene for haemophilia, then the males will have this disorder. As a result, haemophilia is mostly likely to result in men. If women were to have an X chromosome with the defected gene, than they would be a carrier of the disease (Pemberton 2011). While women may not experience the full effects of the disorder, they might experience some of its …show more content…
This factor is also most commonly known as Factor VIII (FVIII), which is the main factor involved with haemophilia. Presently, there four different types of haemophilia: acquired haemophilia, haemophilia A, haemophilia B, and haemophilia C. While acquired haemophilia and haemophilia A both results from a missing or defective clotting protein of FVIII, haemophilia B and C are derived from missing/defective factors of IX and XI, respectively. As each type of haemophilia is different and has its own set of complications, this report mainly focuses on the treatments aim towards haemophilia
Although it has been recognized as a bleeding disorder since the second century, its origins were not discovered until the late 19th century. Haemophilia was known to be a recessive sex-linked disorder as it is carried down generations through the X sex chromosome. Since males have one X and one Y chromosome, if their X chromosome contains the gene for haemophilia, then the males will have this disorder. As a result, haemophilia is mostly likely to result in men. If women were to have an X chromosome with the defected gene, than they would be a carrier of the disease (Pemberton 2011). While women may not experience the full effects of the disorder, they might experience some of its …show more content…
This factor is also most commonly known as Factor VIII (FVIII), which is the main factor involved with haemophilia. Presently, there four different types of haemophilia: acquired haemophilia, haemophilia A, haemophilia B, and haemophilia C. While acquired haemophilia and haemophilia A both results from a missing or defective clotting protein of FVIII, haemophilia B and C are derived from missing/defective factors of IX and XI, respectively. As each type of haemophilia is different and has its own set of complications, this report mainly focuses on the treatments aim towards haemophilia