Effect Of Illness Duration On Cortical Thickness Essay

1412 Words Dec 12th, 2016 6 Pages
Marked neuroanatomical changes have been consistently present in those with schizophrenia. In particular, researchers have observed reductions in cortical thickness. These changes are presumed to be progressive, however, the rate of progression is not consistent with the clinical improvement of many patients (Gou, Palaniyappan, Liddle & Feng, 2016). Guo et al. also note that some studies have found increased thickness in brain regions instead of the decreases others have found (2016). This suggests that neuroprogression may be specific to certain stages of illness, as well as to certain regions of the brain (Guo et al., 2016). Additionally, neuroprogressive changes [redundant?] may be ‘canceled out’ due to increases in other brain regions, in effect, compensating for any losses (Guo et al., 2016). This is especially true for individuals who have had schizophrenia for a longer duration. Guo et al. examined the “effect of illness duration on cortical thickness” to determine whether there is evidence of a compensatory, or ameliorative, process contributing to these changes. Previous studies have only focused on those regions “showing the largest magnitude of group differences”, Guo et al. wanted to, instead, closely examine any covariance among regional thickness (2208, 2016). The researchers also propose that a cross sectional sample including individuals who have had schizophrenia for varying amounts of time could provide “indirect evidence” of a compensatory process (Guo et…

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