How do we store spatial information? It has been known that a sequence of molecular events control the formation and consolidation of spatial memories which, if repeated, get converted into long term memories. Creb, an early response gene, has shown to be involved in formation and consolidation of various forms of memories. Npas4 is master regulator of activity-dependent learning, and sense even a slight change in intracellular calcium level and rapidly induce its downstream genes expression. Here, for the first time we have shown that Npas4, a novel immediate early response gene, has an important role in short term spatial memory
