Clostridium Difficile Research Paper

953 Words 4 Pages
An infectious disease is pathogenic microorganisms, like bacteria, viruses, parasites or fungi that cause diseases by spread, directly or indirectly, from one person to another. One infectious disease is Clostridium difficile, a nasty bacterium that affects the digestive system, specifically the colon. A disease that can start of pretty mild and lead to life-threatening inflammation of the colon. Clostridium difficile is a bacterial infection in the digestive system which has the same symptoms as colitis (inflammation of the colon). C. difficile is bacillus shaped, gram-stained, an endospore former and thrives off in the absence of oxygen. C. difficile is a characterized as a digestive system disease and it affects the colon which causes it …show more content…
difficile can be colitis, which causes the colon to be inflamed, cause diarrhea, fever and abdominal cramps. The discovery of C. difficile was John Bartlett, he began trials investigating the problem of antibiotic-associated diarrhea and pseudomembranous (a layer which resembles a membrane, especially one forming over a mucosal surface) the discovery of Clostridium difficile and he identified it as the leading cause of hospital-associated infections.
The prognosis for C. difficile is being able to recover even without treatment and if not it is perforation (rupture) of the colon and death. If you have had C. difficile infection before, you have a one in four chance of the infection returning, so it is important to get treated right away properly by your physician.
I have looked up on an article that there is current research on the bacterium C. difficile. There is a couple antibiotics that NIAID (National Institute of Allergy and Infectious Diseases) is currently supporting. First, there is “CRS3123” which inhibits an enzyme required by C. difficile to make proteins and then there is “Amixicile” which targets an enzyme found in anaerobic bacteria, like in C. difficile. The NIAID is supporting research that focuses on understanding basic mechanisms of C. difficile spore-formation and spore germination and also the spread within health care facilities. The major difference between C. difficile is that usually you contract it from antibiotic use. It is really tough to tell the difference from C. difficile to other digestive system infections because they usually have all the same symptoms, but C. difficile is more common in hospitals and health care

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