As a result of being a GABA receptor agonist, Clobazam is a long term treatment and not a cure, prior to treatment with Clobazam each patient must be assessed individually for any history of depression and the appropriate precautions taken.[2]
Clobazam produces an inhibitory effect on neurotransmission which has a distinct therapeutic effect on the quantity and strength of seizures experienced by the patient. Seizures are caused by changes in the brains electrical activity above and beyond normal everyday function, this increase can occur as a result of an increase in excitatory neurotransmission, a decrease in inhibitory neurotransmission and any change to ion channels. There are a number of external events that can lead to the development of seizures in the brain, these include head injury, Brain tumors, Infections, stoke, genetic factors or Alzheimer’s to name a few.
There are 2 main types of seizure; -
Generalized Seizures;
These types of seizures occur due to electric impulses throughout the entire brain, there are 6 different type of generalized seizure and they are as follows: