Clobazam Case Study
As a result of being a GABA receptor agonist, Clobazam is a long term treatment and not a cure, prior to treatment with Clobazam each patient must be assessed individually for any history of depression and the appropriate precautions taken.
Clobazam produces an inhibitory effect on neurotransmission which has a distinct therapeutic effect on the quantity and strength of seizures experienced by the patient. Seizures are caused by changes in the brains electrical activity above and beyond normal everyday function, this increase can occur as a result of an increase in excitatory neurotransmission, a decrease in inhibitory neurotransmission and any change to ion channels. There are a number of external events that can lead to the development of seizures in the brain, these include head injury, Brain tumors, Infections, stoke, genetic factors or Alzheimer’s to name a few.
There are 2 main types of seizure; -
These types of seizures occur due to electric impulses throughout the entire brain, there are 6 different type of generalized seizure and they are as follows: …show more content…
Mechanism of Action
Clobazam is a 1,5- benzodiazepine and a GABA receptor agonist. Clobazam does not bind to the neurotransmitter GABA binding site but instead binds to an allosteric site which causes an increase affinity of GABA to the receptor on the neuron. As GABA forms part the chloride Ion channel pathway the increased affinity to the receptor has the knock on effect of increasing the occurrence of the chloride Ion channel opening, which increases inhibitory neurotransmission and results in a reduction in neuronal activity. This reduction in neuronal activity will reduce the amount of seizures seen by the patient.
As per figure 2 below an increase in Clobazam has a large effect on the number of seizures experienced, while it can also be seen that an increase in dose rate does not necessarily give a similar increase in response. Clobazam is manufactured synthetically and is usually administered in a tablet or oral suspension form. The recommended dose rate for 30kg body weight, the recommended max dose increases to 40mg/day, starting at 10mg/day and working towards 40mg/day over a 21 day period. Clobazam has a therapeutic dose level of 50-300µg/ml. The daily dose should be divided into two equal quantities administered morning and