Classifications Of Osteogenesis Imperfecta And Explanations For The Causes Symptoms And Potential Treatment Options For Patients

1373 Words Nov 11th, 2016 6 Pages
Introduction
Colloquially known as “brittle bone disease”,Osteogenesis imperfecta (OI) describes a group of genetic disorders estimated to affect around 7 out 100,000 people around the world. As the name suggests the principal characteristic of osteogenesis imperfecta is the imperfect formation of the bones leading to frequent fractures or breaks from minor trauma (Rauch et al., 2004). Depending on the severity of symptoms the impact on an affected individual 's life can differ. This paper will supply the necessary information for patients or those with family and loved ones afflicted with OI to manage and understand their condition. Focusing on the four main classifications of osteogenesis imperfecta and explanations for the causes, symptoms and potential treatment options for osteogenesis imperfecta.
Classification
Osteogenesis imperfecta is most frequently classified using a system developed by Sillence and colleagues, who confirmed there are at least “ four syndromes” known as osteogenesis imperfecta. Sillence places patients in four clinical categories (Type I, Type II, Type III and Type IV) based on expressed symptoms, the most principal of which is the level of bone fragility (Sillence et al., 1979). Severity of bone fragility runs a touch out of order, but going from least fragile to most fragile is; Type I, Type IV, Type III and Type II. Sillence’s classification system also takes into account multiple extraskeletal including the color of the sclera and the…

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