Charcot Marie-Tooth Disease Research Paper

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Charcot-Marie-Tooth (CMT) Disease
Charcot-Marie-Tooth Disease which is also called CMT. It is said in National Institute of Neurological Disorders and Stroke “That the physicians Jean-Martin Charcot, Pierre Marie, and Howard Henry Tooth. In 1886 Charcot, Marie, and Tooth discovered a group of progressive disorders that affects the peripheral nerves” (NINDS). They still consider this disease to being rare in the United states. The estimated amount of people who are diagnosed is fewer than 175,00 a year and the worldwide estimate is around 2.5 million. Of course, this number can be much more. National Institute of Neurological Disorders and Stroke has said that “CMT is one of the most common inherited neurological disorders” (NINDS). CMT is also known as Hereditary Motor and Sensory Neuropathy is HMSN for short. Which means that this disease runs in families. They cause trouble with motor and sensory nerves.
CMT is caused by a mutation in the genes that proteins are produced that involve the structure and function of the peripheral nerve axon or the myelin sheath. A nerve cell would communicate by send information electrical signals to the axon and increase
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Depending what type of CMT you have the symptoms vary from patients to patients. For many people the have foot drop—is when you have a difficulty lifting the foot at the ankle, so your toes point downward towards the floor. Which make you have an abnormal gait as you walk. People can wear a boot or high top shoes that go around the ankle to help support this problem. So times its others might require wearing ankle-foot orthosis (AFO) which is a cast the is removable that is fitted tightly around the ankle and foot. So those that have a much more proximal weakness than there is the knee-ankle-foot orthosis(KAFO) is extended up the leg and stops above the knee. There is mostly no need for wheelchairs or motorized chairs except for older people or those with severe

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