Case Study Of Linum Usitassimum

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Linum usitassimum is an annual herb belonging to the family Linaceae. The plant is indigenous to west Asia and the Mediterranean. Seed oil of this plant used commercially in the painting and varnishing due to its polymerization properties when exposed to the air and sun light. It is also used as an astringent in fungicidal lotion and an insecticide. Seed oil are reported to rich in essential fatty acids like omega-3- fatty acids (linolenic acid, 35-67%), omega-6- fatty acids (linoleic acid, 8-29%) and omega-9-fatty acids (oleic acid, 12-30%). Other biological compounds lignans, cyanogenic glycosides and cyclic peptides are also reported in flaxseed, but the most biological activity has been reported due to prominent active constituents like …show more content…
Some researcher reported that omega-3- fatty acid (fish oil) exhibited hypoglycaemic effect in type-2 diabetic rats. However long chain polyunsaturated fatty acids like EPA and DHA showed promising effect in diabetes and cardiovascular disease. Kaithwas et al. investigated that treatment with L. usitassimum seed oil (LUSO) at the dose of (1,2,3 mL/kg, i.p.) does not showed any significant changes in blood glucose level in rats for oral glucose tolerance test (OGTT). This effect was observed possibly due to result of short duration of study. Furthermore the LUSO antidiabetic activity was tested in STZ induced diabetic rats. STZ is a diabetogenic compound, it caused diabetes by alteration in pancreatic β cells DNA leads to apoptosis. It also generate very toxic free radical peroxinitrate, damages the cell integrity. LUSO (3ml/kg) exhibited significant reduction in blood glucose and glycated haemoglobin level as compared with diabetic control group in 21 days of study. LUSO reported to have higher proportion of ALA, metabolised in DHA and EPA have glucose lowering potential by preventing the insulin resistance in animals (Prevention of insulin resistance by n-3 polyunsaturated fatty …show more content…
Salim et al. investigated that LUSO (dose; 5%, 20% of meal) significantly suppressed 1,2 dimethylhydrazine (DMH) induced colon carcinogenesis in dose dependant manner. LUSO exerted inhibitory activity of colon cancer by seize the early cell proliferation and altered mucin secretion in colon mucosa in rats. Williams et al. revealed that LUSO at doses of 7% and 14% in AIN-934 based diet attenuated the constitution of aberrant crypt foci (ACF) in azoxymethane induced colon cancer. According to study LUSO (7%) have greater inhibitory activity than LUSO (14%) of ACF. Oil also has cellular protective activity by increasing the phase II hepatic glutathione-S-transferase (GST) enzyme in rats as compared to control group. Result of study indicated that distal region have higher ACF than the proximal colon. They suggested that LUSO showed restrictive activity due to a lignan secoisolariciresinol diglycoside (SDG), known as phytoestrogen, and

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