Case Study Of Linum Usitassimum

Superior Essays
Show More
Linum usitassimum is an annual herb belonging to the family Linaceae. The plant is indigenous to west Asia and the Mediterranean. Seed oil of this plant used commercially in the painting and varnishing due to its polymerization properties when exposed to the air and sun light. It is also used as an astringent in fungicidal lotion and an insecticide. Seed oil are reported to rich in essential fatty acids like omega-3- fatty acids (linolenic acid, 35-67%), omega-6- fatty acids (linoleic acid, 8-29%) and omega-9-fatty acids (oleic acid, 12-30%). Other biological compounds lignans, cyanogenic glycosides and cyclic peptides are also reported in flaxseed, but the most biological activity has been reported due to prominent active constituents like …show more content…
Some researcher reported that omega-3- fatty acid (fish oil) exhibited hypoglycaemic effect in type-2 diabetic rats. However long chain polyunsaturated fatty acids like EPA and DHA showed promising effect in diabetes and cardiovascular disease. Kaithwas et al. investigated that treatment with L. usitassimum seed oil (LUSO) at the dose of (1,2,3 mL/kg, i.p.) does not showed any significant changes in blood glucose level in rats for oral glucose tolerance test (OGTT). This effect was observed possibly due to result of short duration of study. Furthermore the LUSO antidiabetic activity was tested in STZ induced diabetic rats. STZ is a diabetogenic compound, it caused diabetes by alteration in pancreatic β cells DNA leads to apoptosis. It also generate very toxic free radical peroxinitrate, damages the cell integrity. LUSO (3ml/kg) exhibited significant reduction in blood glucose and glycated haemoglobin level as compared with diabetic control group in 21 days of study. LUSO reported to have higher proportion of ALA, metabolised in DHA and EPA have glucose lowering potential by preventing the insulin resistance in animals (Prevention of insulin resistance by n-3 polyunsaturated fatty …show more content…
Salim et al. investigated that LUSO (dose; 5%, 20% of meal) significantly suppressed 1,2 dimethylhydrazine (DMH) induced colon carcinogenesis in dose dependant manner. LUSO exerted inhibitory activity of colon cancer by seize the early cell proliferation and altered mucin secretion in colon mucosa in rats. Williams et al. revealed that LUSO at doses of 7% and 14% in AIN-934 based diet attenuated the constitution of aberrant crypt foci (ACF) in azoxymethane induced colon cancer. According to study LUSO (7%) have greater inhibitory activity than LUSO (14%) of ACF. Oil also has cellular protective activity by increasing the phase II hepatic glutathione-S-transferase (GST) enzyme in rats as compared to control group. Result of study indicated that distal region have higher ACF than the proximal colon. They suggested that LUSO showed restrictive activity due to a lignan secoisolariciresinol diglycoside (SDG), known as phytoestrogen, and

Related Documents

  • Improved Essays

    Phlomis Umbrosa Essay
    • 896 Words
    • 4 Pages

    Phlomis Umbrosa Essay

    Cancer is one of the most life-threatening diseases requiring a lot of development in cures and preventative therapies. A wide variety of anticancer drugs including those that directly or indirectly act on the cells causing cell death have been developed,. Nowadays, natural products have received increasing attention for their potential as novel cancer preventive and therapeutic agents [1,2].…

    • 896 Words
    • 4 Pages
    Improved Essays
    Read More
  • Improved Essays

    Hemp Benefits
    • 682 Words
    • 3 Pages

    Hemp Benefits

    It is the best source of vital fatty acids - its fatty acid content is higher than that of flax or any other nut or seed.…

    • 682 Words
    • 3 Pages
    Improved Essays
    Read More
  • Improved Essays

    American Cancer Society
    • 930 Words
    • 4 Pages

    American Cancer Society

    Cancer — one of the most conversational diseases in the world. Society is constantly trying to figure out ways to help prevent cancer. There are numerous research institutions and organizations that are dedicated to topics related to the prevention of cancer, such as the National Cancer Society, American Cancer Foundation, and American Cancer Society. Cancer is a deadly disease that everyone wants to eliminate from the world. Unfortunately, everyone does not agree on the methods for the prevention of cancer, which strikes a controversy between scientists and the public and scientists between scientists. The tension between scientists arouse when the Harvard School of Public Health reported that they found no link between fruits and vegetables…

    • 930 Words
    • 4 Pages
    Improved Essays
    Read More
  • Great Essays

    Alzheimer's Disease Research Paper
    • 2015 Words
    • 9 Pages

    Alzheimer's Disease Research Paper

    Each different type impacts the body in different ways. Alpha Linolenic Acid (ALA) is a short-chain ɳ-3 fatty acid molecule composed of eighteen carbon atoms and three double bond hinges. ALA is the most abundant form of ɳ-3 fatty acids and is found in plants, including salad greens, and in seeds, such as flax and canola (Sears 24). Eicosapentaenoic Acid (EPA) is made up of twenty carbon atoms and five double bonds and is also mainly found in seafood. Finally, the last and longest form of ɳ-3 fatty acid, Docosahexaenoic Acid (DHA) has twenty-two carbon atoms and six double bond hinges. Like EPA, DHA is mostly contained in seafood. Both EPA and DHA are categorized as highly unsaturated fatty acids (HUFA) (25). The body prefers these longer-chain acids to ALA and uses enzymes to convert ALA into EPA and DHA. Although ALA is considered the parent fatty acid of ɳ-3’s, this conversion is highly inefficient; in fact, recent studies indicate that less than one percent of ALA oils consumed is converted to EPA and an even lower percentage is converted to DHA (Tribole…

    • 2015 Words
    • 9 Pages
    Great Essays
    Read More
  • Improved Essays

    Omega 3 Benefits
    • 382 Words
    • 2 Pages

    Omega 3 Benefits

    Omega-3 improves your cholesterol. While circulates less fat particles in the blood vessels, and the…

    • 382 Words
    • 2 Pages
    Improved Essays
    Read More
  • Decent Essays

    Module 8: A Panacea For Diabetes
    • 78 Words
    • 1 Pages

    Module 8: A Panacea For Diabetes

    Studies testify that the black seed oil decreases the blood glucose levels via increasing the insulin levels (a hormone secreted by the pancreas, which aims to reduce the blood glucose levels normally). However, since, the diabetics are usually insulin resistant or insulin-deficient; their blood glucose levels remain on the higher side. Backed up by animal studies, the glucose lowering effects of the black seed oil demonstrate its efficacy as a natural antidiabetic cure.…

    • 78 Words
    • 1 Pages
    Decent Essays
    Read More
  • Improved Essays

    Type 2 Diabetes Research Paper
    • 589 Words
    • 3 Pages

    Type 2 Diabetes Research Paper

    Insulin resistance is found to be a chief metabolic problem of many cases of type 2 diabetes. Insulin resistance is known to be the reduced ability of circulating insulin to result in cellular glucose uptake. Glucose is known as the major energy substrate for numerous tissues. Insulin acts by stimulating its receptor on the cell surface. This sets up a flow of phosphorylation steps of subcellular enzymes that are maintained by key regulators. “The ultimate result is the movement of a glucose transporter, glucose transporter 4 (GLUT4), from the cell cytosol to the cell surface, and this permits glucose uptake into the cell.” Within this intricate path, there are several points where the signaling may be disturbed and form mutations. Seldom do genetic mutations in the insulin receptor or its substrate result in insulin resistance. More commonly, increased circulating fatty acids interfere with insulin signaling through a mechanism called lipotoxicity. Also, low-grade systemic inflammation is often found in obesity;…

    • 589 Words
    • 3 Pages
    Improved Essays
    Read More
  • Improved Essays

    Cancer Awareness Essay
    • 1397 Words
    • 6 Pages

    Cancer Awareness Essay

    Today cancer kills 7.6 million people every year and the casualties from cancer have only risen over the years. Because of the rising numbers in cancer caused deaths it leads to questions as to what may be causing the large increase. There are many different factors that play a role into our everyday life that play a role in potentially increasing our chances of being diagnosed with cancer. One in three adults will be diagnosed with cancer in their lifetimes and we are slowly discovering different mutagens and carcinogens that make this statistic a reality. Factors like alcohol consumption, sun exposure, tobacco use, exposure to pesticides, and the cooking method of meat are all large contributors to these carcinogens and cancer causing mutagens.…

    • 1397 Words
    • 6 Pages
    Improved Essays
    Read More
  • Improved Essays

    Fish Oil Research Paper
    • 1951 Words
    • 8 Pages

    Fish Oil Research Paper

    In their study, they had three groups: group one was supplemented with sunflower oil, group two was supplemented with fish oil, and group three was supplemented with a combination of both fish oil and vitamin E. These three groups were given these supplements respectively for twelve weeks. After twelve weeks, the researchers administered lipopolysaccharides intravenously in order to induce inflammation. They then took samples and evaluated the serum activity multiple times over the course of six hours. The dogs that were supplemented with fish oil had significantly less PGE2, which supports fish oil as a valid anti-inflammatory treatment and to assist in reducing the problems caused by chronic inflammatory diseases. They found that the ideal supplementation from fish oil was with 1.75 g of EPA/kg of diet and 2.2 g of DHA/kg of diet on a dry matter basis as it had the greatest reducing…

    • 1951 Words
    • 8 Pages
    Improved Essays
    Read More
  • Improved Essays

    Summary: The Link Between Meat And Cancer
    • 535 Words
    • 3 Pages

    Summary: The Link Between Meat And Cancer

    The last factor the author discusses is the concept of mutagens from cooking, such as high temperature, which can overall generate dangerous compounds such as heterocyclic amines and polycyclic aromatic hydrocarbons- both known to actually mutate one’s DNA itself and increases the risk of disease such as cancer, and several others. The author does however mention that multiple studies indicate that several starchy vegetables can suppress tumors indicated by the factors mentioned in the…

    • 535 Words
    • 3 Pages
    Improved Essays
    Read More
  • Improved Essays

    Omega 3s Research Paper
    • 347 Words
    • 2 Pages

    Omega 3s Research Paper

    There are two different sources of omega-3s-seafood and plants. Fatty fish, such as salmon and herring, are the best sources of two omega-3s-eicosapentenoic acid (EPA) and docosahexenoic acid (DHA). These fats help reduce blood clots (a cause of heart attacks), arrhythmias, inflammation (increasingly implicated in heart disease), and high blood pressure. They also help lower triglycerides (fats in the blood). That's why the American Heart Association recommends at least two servings of fish a week for general heart health, and higher levels for people who already have heart disease. Since September, 2004, foods containing EPA and DHA have been able to carry a qualified health claim linking their consumption to a reduced risk of heart…

    • 347 Words
    • 2 Pages
    Improved Essays
    Read More
  • Improved Essays

    Broccoli Prevents Cancer
    • 555 Words
    • 3 Pages

    Broccoli Prevents Cancer

    The main claim in the article is that broccoli and other cruciferous vegetables have a compound called sulforaphane that proved can help prevent cancer or slow its progression. They also claim that lncRNA has emerged as a key player in the development of cancer. With sulforaphane, the lncRNA can be reduced. To prove this idea, the writer includes a test that resulted in sulforaphane can actually reduce levels of lncRNA.…

    • 555 Words
    • 3 Pages
    Improved Essays
    Read More
  • Improved Essays

    Cardiac Dysfunction
    • 359 Words
    • 2 Pages

    Cardiac Dysfunction

    On the other hand, a significant increase was observed in GSH levels, SOD and CAT activities in liver in the group that was given DOX and omega-3. This might indicate that omega-3 have a protective effect against DOX-induced oxidative damage. omega-3 treatment prevents oxidative damage. Takayama et al. (2010) reported that hepatic antioxidant enzymes increased, while hepatic lipid peroxide concentrations prominently…

    • 359 Words
    • 2 Pages
    Improved Essays
    Read More
  • Improved Essays

    N-3 LCPUFA Analysis
    • 424 Words
    • 2 Pages

    N-3 LCPUFA Analysis

    The supplementation with 1 g/day of DHA+EPA in these patients increased levels of these fatty acids in the heart tissue, erythrocytes, plasma and buccal cells by 110%, 101%, 139% and 73% respectively (Harris et al., 2004). The correlation of n-3 PUFA levels between cardiac tissue and RBC concentration was high (r = 0.82; P that refers to the levels of EPA+DHA on erythrocytes (Harris et al., 2004; Harris & von Schacky, 2004). These results suggest that erythrocyte fatty acids could be a biomarker for determining n-3 LCPUFA levels in the heart and also act as a marker for cardiovascular disease (Harris & von Schacky, 2004). The results suggest that the use of buccal cells may tend to under-estimate EPA+DHA values. In addition, Analysis of these studies suggests that erythrocytes and plasma may both be good biomarkers for n-3 PUFA dietary status. However, the fatty acid content of erythrocytes reflects dietary intake for more than a month (approximate half-life of erythrocytes) while that in plasma reflects that of a few days or meals (Arab, 2003). Serum fatty acids are known to fluctuate rapidly,…

    • 424 Words
    • 2 Pages
    Improved Essays
    Read More
  • Improved Essays

    Cancer, Malignant Tumors
    • 460 Words
    • 2 Pages

    Cancer, Malignant Tumors

    The esophagus, in particular, is highly vulnerable to the combined effects of exposure to environmental carcinogens and malnutrition, particularly in certain extreme environments of the developing world. Even in high-income countries, dietary carcinogens and nutrition play a major role in the etiology of oropharyngeal, esophageal and, to a lesser extent, gastric cancers, but the mechanisms are poorly understood. Thus, dietary modifying is essential to prevent occurrence of oral, esophageal, stomach and colon cancer. Based on Diet, nutrition and the prevention of cancer by Public Health Nutrition, overweight/obesity increases the risk for cancers of the oesophagus (adenocarcinoma) and colorectal, alcohol causes cancers of the oral cavity, pharynx, oesophagus and liver, fruits and vegetables probably reduce the risk for cancers of the oral cavity, oesophagus, stomach and colorectal, and diets should include at least 400 g/d of total fruits and vegetables. Preserved meat and red meat probably increase the risk for colorectal cancer; if eaten, consumption of these foods should be moderate. Salt preserved foods and high salt intake probably increase the risk for stomach cancer; overall consumption of salt preserved foods and salt should be moderate. Very hot drinks and foods probably increase the risk for cancers of the oral…

    • 460 Words
    • 2 Pages
    Improved Essays
    Read More

Related Topics

Ready To Get Started?
Discover
Company
Follow
©2023 Cram.com
Privacy Policy |  About Ads |  Site Map |  Advertise  | 
  • Cookie Settings