Breast Cancer : The Third Most Common Cancer For Women Worldwide
Ovarian cancer (OC) is the seventh most common cancer for women worldwide in 2012(1). In Canada, 17,000 women are living with ovarian cancer, and it is ranked the fifth most common cancer for Canadian Canadian women in 2013(2). According to the recently released surveillance report, 2,700 new cases will be diagnosed in 2014 in Canada?(3). Moreover, it is the most fatal women’s cancer, with the average of 45% 5-year survival rate comparing to 89% of the survival rate for women with breast cancer(4). The 5 year survival rate is only 5% for those who were diagnosed with the most advanced stage disease compared to 75% of survival rate at early stage(5). However, most of the OC patients are diagnosed at the advanced stage, e.g. 51% of OC cases were diagnosed at stage III, which by then the cancer has already spread to other parts of the body. Therefore, even the treatment has made significant progress, the relapse rate remains as high as 70% in OC patients with advanced stage, and the relapse rate is around 20-25% in patients with early stage I/II (6).
Rational of the study
Currently, the standard approach for OC treatment is through intensive surgical staging and cytoreduction, supplemented with the primary chemotherapy, e.g. carboplatin, paclitaxel and adriamycin as single treatment or Carboplatin-paclitaxel, gemcitabin-cisplatin as combination treatment(7). To be more specific, surgery, chemotherapy, and/or radiation therapy are applied to OC patients who were…