Breast cancer is a dangerous form of cancer. Although there are many survivors there are also many who don’t survive. There are many different types of cancers. What is triple negative breast cancer (TNBC)? Triple-Negative Breast Cancer is when the three most common types of receptors know to fuel or help grow most breast cancers are not present in the cancer tumor. Which means that the cancer cells have tested negative for hormone growth factor receptor 2 (HER-2), estrogen receptors (ER), and progesterone receptors (PR). Hormone therapy and drugs that target estrogen, progesterone, and HER-2 but since the tumor cells lack the necessary receptors these treatments are ineffective. Chemotherapy is still a very effective way to treat triple negative
…show more content…
Usually women under 50.Women who have the BRCA1 gene mutations are also more likely to develop it as are African-American and Hispanic women. Scientists have spent quite a bit of time over the last year evaluating a protein called the folate receptor alpha protein. In the Mayo clinic inside the laboratory they studied a variety of tumor types and they identified approximately 80% of the cases of TNBC, this protein was over-expressed. Only patients with resected or removed TNBC whose tumors express that protein will be eligible. During a mammogram TNBC is less likely to be found then other types of breast cancers. TNBC tends to grow more rapidly than other types of cancers. Part of the reason this cancer usually comes back is because of the lack of treatments available. There is a poorer outcome for at least the first five years after you are diagnosed with TNBC which means that a lot of people die within the first five years after diagnosed, compared to estrogen receptor-positive tumors. If TNBC hasn’t come back within 5 years, the survival is higher than those of ER+ tumors which have a lower chance of survival. This is good news for five-year survivors.
Most triple-negative breast cancers are believed to be the basal-like cell type. Researchers have identified using gene analysis technology that “Basal-like cell type” is a new subtype of breast cancer. Which means that
Usually women under 50.Women who have the BRCA1 gene mutations are also more likely to develop it as are African-American and Hispanic women. Scientists have spent quite a bit of time over the last year evaluating a protein called the folate receptor alpha protein. In the Mayo clinic inside the laboratory they studied a variety of tumor types and they identified approximately 80% of the cases of TNBC, this protein was over-expressed. Only patients with resected or removed TNBC whose tumors express that protein will be eligible. During a mammogram TNBC is less likely to be found then other types of breast cancers. TNBC tends to grow more rapidly than other types of cancers. Part of the reason this cancer usually comes back is because of the lack of treatments available. There is a poorer outcome for at least the first five years after you are diagnosed with TNBC which means that a lot of people die within the first five years after diagnosed, compared to estrogen receptor-positive tumors. If TNBC hasn’t come back within 5 years, the survival is higher than those of ER+ tumors which have a lower chance of survival. This is good news for five-year survivors.
Most triple-negative breast cancers are believed to be the basal-like cell type. Researchers have identified using gene analysis technology that “Basal-like cell type” is a new subtype of breast cancer. Which means that