Benefits Of Designing A Combination Therapy Of Active Treatment And Imaging Agent For Use Patients With Coronary Artery Disease

952 Words Aug 1st, 2014 4 Pages
1. In 500 of your own words describe the benefit of designing a combination therapy of active treatment and imaging agent for use in patients with coronary artery disease.

Cardiovascular disease is the main cause of the global mortality and morbidity of 17 million people. Surgical procedures currently combating this disease are percutaneous coronary angioplasty and coronary artery bypass grafting; both risking vein graft failure or restenosis; requiring further surgical intervention, drug or gene treatment. (Thomas, 2012)
Target local drug delivery treatment (TLDD) was established to overcome systemic drug delivery complications and side effects of toxicity, high cost (repeated dosage) and low patient compliance. Also systemic gene administration risks unnecessary allocation and gene ‘wash out’ and TLDD’s high localising drug concentration requires less medication, produces lower toxicity; thereby increasing the activity and bioavailability of drugs, enhancing vascular repairs and reducing systemic complications. (Thomas, 2012)
Physical and active techniques are used for local delivery of drugs and active agents. Physicals techniques used are delivery catheter, coated stent, adventitial delivery and brachytherapy, to name a few. However, active methods used are using antibodies or targeting peptide to aim the drug at specific targets. In addition, nanoparticles have been used recently to improve the delivery and bioavailability of the active agent. (Wilensky, 2010). A…

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