Pre Formulation Study Essay

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9. RESULTS
Table 8: Pre Formulation Study
S.NO API CHARACTERISATION RESULTS
1 Physical Appearance a white to slightly pink crystalline powder
2 Melting point 138-148 ºC
3 Bulk density 0.396 gm/ml
4 Tapped Density 0.421 gm/ml
5 Carr’s index/Compressibility index 5.94
6 Hausner’s Ratio 1.063

Conclusion:
The value of compressibility index above 25%, 15-25%, less than10% indicates poor flowability, optimum flowability and high flowability respectively. As Efaverinz value is <10 so it exhibits good flow.
Table 9: SOLUBILITY STUDIES:
Solvent Solubility (mg/ml)
Water 0.123
Polyethylene Glycol-400 2.253
Propylene Glycol 20.52
Tween 80 9.653333
Buffer pH (6.8) 0.194

DRUG POLYMER INTERACTION STUDY: From the spectra of Efaverinz, combination of Efaverinz with excipient, it was observed that all characteristic peaks of Efaverinz were present in the combination spectrum, thus indicating compatibility of the drug and excipient. IR spectra are shown in Fig:
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Fig no: 3 IR spectra of Efaverinz IR spectra of Efaverinz+PG IR spectra of Efaverinz+Polysorbate-80 IR spectra of Efaverinz+PEG-400 IR spectra of Efaverinz+MCC+AEROSIL Fig no: 10 IR spectra of the Optimized Formulation
Table 10: STANDARD CALIBRATION CURVE FOR EFAVERINZ IN 6.8 PHOSPHATE BUFFER of 2% SLS:
CONCENTRATION (µg/ml) ABSORBANCE (nm)
0 0
2 0.077
4 0.138
6 0.211
8 0.281
10 0.352

Figure 11:Standard calibration curve for

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