Alzheimer's Disease Hypothesis

Alzheimer’s disease (AD) is one of the major causes for dementia, the majority of the people affected by the age. It has been estimated that by 2050, 88 million of the world population will have the Alzheimer’s disease. There are different types of Alzheimer’s disease; for instances, autosomal dominant and sporadic. However, there has not been any permanent treatment identified for this disease. There are several hypotheses stated for the occurrence of Alzheimer’s disease. Major hypothesis is Amyloid beta hypothesis; which states that the accumulation of amyloid beta protein in the brain tissue predominantly cause the Alzheimer’s disease. The two papers discuss about research based on the Amyloid beta hypothesis. The first paper talks about the biomarker changes in autosomal dominant Alzheimer’s …show more content…
However, majority of pathology in Autosomal dominant type is similar to the sporadic type of AD. The major criteria they have been discussed are, the concentration changes of Aβ1-42 and tau protein in cerebral spinal fluid (CSF) over the years, the change of cognitive functions and cerebral hypo- metabolism. They have identified the onset for each of these changes in carriers for the Autosomal AD. These findings have great impact on identifying the symptoms early for the mutation carriers and for the non-carriers. The second paper discusses about how these major findings based on the amyloid beta hypothesis have contributed in support of the Amyloid beta hypothesis and furthermore it discussed possible modifications to the hypothetical model. The modified hypothetical model is more focus on the time of the symptom development rather than the symptom severity, by considering the individual variables. The major findings from both the papers would contribute in identifying basic reasons behind the disease, moreover, in finding a treatment for Alzheimer’s