P53

and it is altered in many types of cancer. It has been shown to contain one of the initiating mutations in the majority of ulcerative colitis-associated neoplasias; however, the role of p53 in salivary gland neoplasms is controversial and needs to be clarified.…

Hereditary Cancer Cancer is one of the most unknown subjects in the medical world. When it comes, why it comes, and how to effectively contain it is still being studied. Treatments have been available to lessen the cancer, or in some cases, take it away. The medical community has come so far in our knowledge of cancer. Splitting cancer into two specific groups of somatic cancer and hereditary cancer, researchers are getting more information. By understanding how hereditary cancer is formed,…

syndrome adds more difficulty to your treatment plans?” Ella- “ Yes, exactly and my syndrome also causes a mutation in the p53 gene, which is a tumor suppressor gene(Family). This is why cancer can develop because the gene is suppose to stop abnormal cells from growing, but the mutation prevents this(Family). Li-Fraumeni syndrome can also be a mutation in the CHEK2 gene, but the p53 gene may play a role in the development of up to 50 % of all cancers(Cooper).” Tori- “ Does knowing all of this…

. SIRT1 is one of the many vital genes that is highly controlled during caloric restriction, which leads to a number of biological variations to extend lifespan. Resveratrol’s activation of the SIRT1 gene affects a number of cellular processes. Resveratrol decreases nuclear factor kappa B (NFκB) activation.The nuclear factor kappa B is located in the cellular cytoplasm and moves to the nucleus upon activation where it stimulates transcription of multiple pro- inflammatory genes such as TNFα,…

package and available through the Bioconductor repository: https://www.bioconductor.org/packages/SRGnet. 2.6. Data Polysomal RNA expression was previously measured in young adult mouse colonic epithelium (YAMC) in four conditions: YAMC control, mutant p53-expressing (mp53), activated Ras-expressing, and both mutant genes (mp53/Ras) cells using Affymetrix GeneChip® Mouse Genome 430 2.0 Arrays (McMurray, et al., 2008). The raw data are available via the Gene Expression Omnibus with accession…

1. Overview Neuroblastoma is a type of cancer that is formed in many different types of nervous tissue. In 1864 a German physician named Rudolph Virchow first described this cancer as a abdominal tumor. The cancer cell appears on adrenal glands mostly and can cause pain in abdomen bones. This cancer mostly shows in 10 year olds and younger , reason why has still not been proven , but scientist do say neuroblastoma develops in early age. Neuroblastoma has two stages , 4 and 4s. Stage for is when…

Cancer is a disease affecting the world and the rise in treatments with drugs is just one way of delaying the process of the disease as well as improving the quality of life for the patient. Henceforth Amsacrine is one to watch out for due to its specific mode of action. Reference. Amsacrine has an acridine chromophore with an amine at the 9 position (fig 1.) used in the treatment of some types of lymphoma or acute adult leukaemia [5]. It can also be known as Amsidine or m-AMSA [1]. Lymphoma…

In the Hallmarks of cancer, the cancer cells are that which, when in the body, tries to avoid being killed off (apoptosis). Once a cell does happen to die, the cell membrane shrinks down and the cell to the next of it will devour the rest of the pre existing cell. When a cancer cell that make up a tumor needs to grow large, the tumor then depends on the blood vessels to nourish upon. The tumor rely on the nutrients as such; oxygen, glucose, and amino acids. The waste that expels out of the cell…

demonstrated that the human HDM2 promoter is a target of the MEF transcriptional factor and the overexpression of MEF led to an increase in the Mdm2 protein (mice version of the human Hdm2), which in turn decreased the expression of the tumor-suppressor, p53, thereby augmenting transformation that may lead to leukemogenesis. Furthermore, the mutation commonly found in leukemia patients resulted in the delocalization of the NPM1 protein from the nucleolus to the…

sufficient DNA damage in cells, but the author puts it into its own specific relation to the clock. The circadian clock has recently been connected to both intrinsic and extrinsic apoptosis. The gene p53 is generally the dominant effector in promoting apoptosis in response to damaged DNA. However, if p53 is mutated (often the case in cancer) a clock regulated gene, p73, becomes a second-order effector for DNA damage during intrinsic apoptosis. It is also mentioned that considerable evidence…