P53

Fairy tales have been shared around the campfire, in homes, in schools, and before bedtime for centuries. First told orally, these stories were passed down from generation to generation until they were eventually written down and collected for consumption by the public. Due to the passing of time and fallibility the stories have changed throughout the years and slightly differ from culture to culture, however, Stories such as Cinderella can be found in historical records from as far back as the…

IHC4 by Genoptix Medical Laboratory. Mammostrat is an IHC-based panel assay that can estimate risk of recurrence in hormone receptor-positive, early stage breast cancer patients which is independent of proliferation and grade. This assay quantifies p53, HTF9C, CEACAM5, NDRG1 and SLC7A5 by a defined mathematical algorithm resulting in a risk index (Bartlett et al., 2012; Bartlett et al., 2010). Similarly, IHC4 is another emerging assay which estimates recurrence risk for early stage breast cancer…

the family tree of most breast cancer victims. From the findings, it was noted that 15% to almost 20% of the breast cancer cases could be attributed to genetic disorders. In the study the genetic cause of cancer was linked to a specific gene known as p53. It is the gene responsible in the contraction and causing of cancer in women. For women possessing this gene, the chances or risk factor of contracting and developing breast cancer increases by almost 16 times than those who do not possess it.…

the heart, an organ that has a relatively low level of antioxidant enzymes such as superoxide dismutase (SOD) and catalase. Others studies propose that the mechanism of DOX-induced heart apoptosis is dependent on the activation of tumor suppressor p53 [9] [10]. Melatonin (MEL), is the chief secretory product of the pineal gland of all mammals. During the day the pineal gland is inactive, when the sun goes down and darkness occurs, the pineal gland is activated and starts to actively produce…

structural insights into the regulation of SIRT1 activity by RES (34). In the proposed model, each SIRT1 can bind to three RES molecules (Figure 5A). Two of these RES molecules make hydrogen bonds with both the extended N-terminal domain (NTD) and the p53-AMC, while the third RES molecule contacts the catalytic domain of SIRT1 (Figure 5B). The individual RES molecules are packed into preformed protein pockets in which a close network of hydrophobic and van de Waals interactions are possible…

of the three subtypes. Large cell carcinoma can be found in any part of the lungs and tends to grow and spread quickly. The development of non-small cell lung cancer involves the loss of heterogeneity of tumor suppressor genes, such as Ras, p16, and p53. In some patients, a mutation…

These claims are to say the least, unbalanced truths. By the end of this discussion it would have become obvious that there is no basis for undue generalizations in the management of cancer. There still remains the need for expert judgement in formulating a cancer treatment protocol. BEFORE CANCER First, let me state that the human body will literally rust away like a nail left under the rain over time without inbuilt natural protective mechanisms. To prevent rust or oxidation, most…

Don't you hate it when people blame you for things you didn't do? Well, I do for sure, and that's what happened to the pig, Snowball in George Orwell’s Animal farm. Snowball, who was a pig, was made a scapegoat for Napoleon and Squealer. The things that Snowball was blamed for are important, but not as important as how he was blamed for them. Snowball was blamed behind his back, for unfortunate things that had happened after he was kicked out of the farm. Napoleon and Squealer would gang up on…

Lung Cancer Lung cancer is a malignant neoplasm of the lung tissue characterized by an uncontrolled cell proliferation. It is also referred to as carcinoma of the lung. This neoplasm arises from epithelia of the lungs, bronchi and trachea. Lung cancers can be of epithelial cell origin (carcinoma) or mesothelial cell origin (malignant mesothelioma). Lung cancer begins with inactivation of tumor suppressor genes or with activation of oncogenes. Carcinogens bring about mutation in the genes that…

it is suspected that the occurence rate of genotype 1b is noted elevated in patients who have worsening liver destruction in histology view. Furthermore, tumor suppression and DNA repair have been impaired by restrict binding of NS5A protein and P53. (2) This mechanism also presented inhibition of T-cell proliferation which plays critical role in immune system. In core proteins, genetic mutations have been detected as a risk factor. It is not significant yet impairment of microRNA to…